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Lack of cerebrospinal fluid myelin basic protein in HIV- infected asymptomatic individuals with intrathecal synthesis of IgG

Department of Neurology, Wilford Hall USAF Medical Center, San Antonio, TX (Drs. Marshall and Brey)
Clinical Investigations Directorate, Wilford Hall USAF Medical Center, San Antonio, TX (Dr. Butzin).

We evaluated 130 consecutive HIV-infected neurologically asymptomatic individuals for intrathecal IgG production and myelin basic protein (MBP) levels. Although 56.7% of immunologically normal and 68.8% of immuno-compromised patients had some CSF abnormality, no patient had an abnormal MBP level. The lack of MBP elevation in the CSF of these patients suggests that the production of intrathecal IgG is not related to active demyelination.

Address correspondence and reprint requests to Dr. Marshall, WHMC/SGHMN, Lackland AFB, TX 78236-5300.

Received August 19, 1988. Accepted for publication in final form February 21, 1989.