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Department of Neurology, National Institutes of Health, Bethesda, MD (Drs. Petroff and Prichard)
Department of Neurosurgery, Yale University, New Haven, CT (Dr. Spencer)
Department of NINDS, National Institutes of Health, Bethesda, MD (Dr. Alger)
We analyzed specimens of histologically normal human cerebrum obtained at surgery for medically refractory epilepsy using proton magnetic resonance spectroscopy. Perchloric acid extracts of anterolateral temporal lobe cortex contained greater concentrations of creatine, N-acetylaspartate, 
-aminobutyric acid, alanine, and glutamate than the underlying white matter, which contained more acetate. Frontal and temporal lobe specimens composed of both gray and white matter failed to show statistically significant differences in the concentrations of creatine, N-acetylaspartate, alanine, aspartate, -aminobutyric acid, glutamate, glycine, taurine, threonine, valine, acetate, choline, ß-hydroxybutyric acid, inositols, lactate, pyruvate, or succinate.
Address correspondence and reprint requests to Dr. Petroff, Department of Neurology, 333 Cedar Street, New Haven, CT 06510.
Supported by grants from the United States Public Health Service (AM30287, NS21708, and NS06208).
Received December 22, 1988. Accepted for publication in final form March 14, 1989.
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