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NEUROLOGY 1990;40:1793
© 1990 American Academy of Neurology

Eosinophilia-myalgia syndrome (l-tryptophan-associated neuromyopathy)

George K. Turi, MD, Gilbert B. Solitare, MD, Nicholas James, MD and Randi Dicker, BS

Departments of Pathology (Drs. Turi and Solitare) and Medicine (Dr. James), Winthrop-University Hospital, Mineola, NY; and the State University of New York (R. Dicker), Stony Brook, NY.

Histopathologic study of skeletal muscle biopsy in a patient with eosinophilia-myalgia syndrome following l-tryptophan use showed prominent lymphocytic perineuritis, neuritis, and perimysial fasciitis. The presence of perineuritis and neuritis provides a histopathologic basis for clinical features of neuropathy in eosinophilia-myalgia syndrome and occurred in conjunction with a fasciitis or interstitial myositis that was predominently perimysial and focally endomysial.

Address correspondence and reprint requests to Dr. Gilbert B. Solitare, Department of Pathology, Winthrop-University Hospital, Mineola, NY 11501.

Received January 22, 1990. Accepted for publication in final form April 17, 1990.






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