| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Neurology (Drs. Jackson, Berkovic, and Bladin), Neurosurgery (Mr. Fabinyi), and Anatomical Pathology (Dr. Kalnins), Austin Hospital, Heidelberg, Victoria, Australia, and the Department of Radiology (Dr. Tress), University of Melbourne, Victoria, Australia.
Two independent blinded observers reported the preoperative MRIs in a series of 81 consecutive patients with intractable temporal lobe epilepsy who were undergoing temporal lobectomy. We then compared the nature and lateralization of the MRI abnormalities with the pathologic diagnosis and the side of lobectomy. The MRI criteria of hippocampal sclerosis were an increased T2-weighted signal and the signal's confinement to a unilaterally small hippocampus. Imaging was performed in coronal and axial planes, specially orientated along and perpendicular to the long axis of the hippocampal body. We found diagnostic MRI abnormalities in 25 of the 27 cases with pathologically proven hippocampal sclerosis (sensitivity 93%, specificity 86%). In addition, we detected all 13 foreign tissue lesions on MRI. Overall, we detected lateralized lesions on MRI that correctly predicted the side of the epileptogenic temporal lobe in 72 cases (89%), with 2 possible errors. A learning effect in appreciating the relatively subtle MRI changes of hippocampal sclerosis was apparent in our later cases, as shown by an improved correlation between the 2 observers. This study demonstrates that hippocampal sclerosis can be identified on MRI with a high degree of sensitivity and specificity.
Address correspondence and reprint requests to Dr. Samuel F. Berkovic, Department of Neurology, Austin Hospital, Heidelberg (Melbourne), Victoria 3084, Australia.
Dr. Berkovic was supported by the National Health and Medical Research Council of Australia.
Received April 2, 1990. Accepted for publication in final form May 22, 1990.
This article has been cited by other articles:
|
|
 |
|
  M Peltola, K Kaukinen, P Dastidar, K Haimila, J Partanen, A-M Haapala, M Maki, T Keranen, and J Peltola Hippocampal sclerosis in refractory temporal lobe epilepsy is associated with gluten sensitivity J. Neurol. Neurosurg. Psychiatry, June 1, 2009; 80(6): 626 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hanamiya, Y. Korogi, S. Kakeda, N. Ohnari, K. Kamada, J. Moriya, T. Sato, M. Kitajima, N. Akamatsu, and S. Tsuji Partial Loss of Hippocampal Striation in Medial Temporal Lobe Epilepsy: Pilot Evaluation with High-Spatial-Resolution T2-weighted MR Imaging at 3.0 T Radiology, June 1, 2009; 251(3): 873 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Provenzale, D. P. Barboriak, K. VanLandingham, J. MacFall, D. Delong, and D. V. Lewis Hippocampal MRI Signal Hyperintensity After Febrile Status Epilepticus Is Predictive of Subsequent Mesial Temporal Sclerosis Am. J. Roentgenol., April 1, 2008; 190(4): 976 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ozturk, D.M. Yousem, A. Mahmood, and S. el Sayed Prevalence of Asymmetry of Mamillary Body and Fornix Size on MR Imaging AJNR Am. J. Neuroradiol., February 1, 2008; 29(2): 384 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.A. Bartlett, M.R. Symms, S.L. Free, and J.S. Duncan T2 Relaxometry of the Hippocampus at 3T AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1095 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-t. Ng, A. L. McGregor, D. C. Duane, H. K. Jahnke, C. R. Bird, and J. W. Wheless Childhood Mesial Temporal Sclerosis J Child Neurol, June 1, 2006; 21(6): 512 - 517. [Abstract] [PDF]
|
|
|
|
 |
|
 A. M. McIntosh, R. M. Kalnins, L. A. Mitchell, G. C. A. Fabinyi, R. S. Briellmann, and S. F. Berkovic Temporal lobectomy: long-term seizure outcome, late recurrence and risks for seizure recurrence Brain, September 1, 2004; 127(9): 2018 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Urbach, J. Hattingen, J. von Oertzen, C. Luyken, H. Clusmann, T. Kral, M. Kurthen, J. Schramm, I. Blumcke, and H. H. Schild MR Imaging in the Presurgical Workup of Patients with Drug-Resistant Epilepsy AJNR Am. J. Neuroradiol., June 1, 2004; 25(6): 919 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Mitchell, A. S. Harvey, L. T. Coleman, S. A. Mandelstam, and G. D. Jackson Anterior Temporal Changes on MR Images of Children with Hippocampal Sclerosis: An Effect of Seizures on the Immature Brain? AJNR Am. J. Neuroradiol., September 1, 2003; 24(8): 1670 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Stroup, J. Langfitt, M. Berg, M. McDermott, W. Pilcher, and P. Como Predicting verbal memory decline following anterior temporal lobectomy (ATL) Neurology, April 22, 2003; 60(8): 1266 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U C Wieshmann Clinical application of neuroimaging in epilepsy J. Neurol. Neurosurg. Psychiatry, April 1, 2003; 74(4): 466 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Zimmerman and J. I. Sirven An Overview of Surgery for Chronic Seizures Mayo Clin. Proc., January 1, 2003; 78(1): 109 - 117. [Abstract] [PDF]
|
|
|
|
|
|
E. L. So Role of Neuroimaging in the Management of Seizure Disorders Mayo Clin. Proc., November 1, 2002; 77(11): 1251 - 1264. [Abstract] [PDF]
|
|
|
|
|
|
S. Coste, P. Ryvlin, M. Hermier, K. Ostrowsky, P. Adeleine, J. C. Froment, and F. Mauguiere Temporopolar changes in temporal lobe epilepsy: A quantitative MRI-based study Neurology, September 24, 2002; 59(6): 855 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Grunewald Childhood seizures and their consequences for the hippocampus Brain, September 1, 2002; 125(9): 1935 - 1936. [Full Text] [PDF]
|
|
|
|
|
|
R. S. Briellmann, R. M. Kalnins, S. F. Berkovic, and G. D. Jackson Hippocampal pathology in refractory temporal lobe epilepsy: T2-weighted signal change reflects dentate gliosis Neurology, January 22, 2002; 58(2): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Wolf, D. C. Alsop, I. Levy-Reis, P. T. Meyer, J. A. Maldjian, J. Gonzalez-Atavales, J. A. French, A. Alavi, and J. A. Detre Detection of Mesial Temporal Lobe Hypoperfusion in Patients with Temporal Lobe Epilepsy by Use of Arterial Spin Labeled Perfusion MR Imaging AJNR Am. J. Neuroradiol., August 1, 2001; 22(7): 1334 - 1341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lamusuo, L. Jutila, A. Ylinen, R. Kalviainen, E. Mervaala, M. Haaparanta, S. Jaaskelainen, K. Partanen, M. Vapalahti, and J. Rinne [18F]FDG-PET Reveals Temporal Hypometabolism in Patients With Temporal Lobe Epilepsy Even When Quantitative MRI and Histopathological Analysis Show Only Mild Hippocampal Damage Arch Neurol, June 1, 2001; 58(6): 933 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hammers, M.J. Koepp, C. Labbe, D.J. Brooks, M. Thom, V.J. Cunningham, and J.S. Duncan Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy Neurology, April 10, 2001; 56(7): 897 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Park, K.-H. Chang, H.-D. Kim, I. C. Song, D. S. Lee, S. K. Lee, C.-K. Chung, I. K. Yu, M. H. Han, and Y. H. Park Lateralizing Ability of Single-voxel Proton MR Spectroscopy in Hippocampal Sclerosis: Comparison with MR Imaging and Positron Emission Tomography AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 625 - 631. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Driessen, J. Herrmann, K. Stahl, M. Zwaan, S. Meier, A. Hill, M. Osterheider, and D. Petersen Magnetic Resonance Imaging Volumes of the Hippocampus and the Amygdala in Women With Borderline Personality Disorder and Early Traumatization Arch Gen Psychiatry, December 1, 2000; 57(12): 1115 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hirai, Y. Korogi, K. Yoshizumi, Y. Shigematsu, T. Sugahara, and M. Takahashi Limbic Lobe of the Human Brain: Evaluation with Turbo Fluid-attenuated Inversion-Recovery MR Imaging Radiology, May 1, 2000; 215(2): 470 - 475. [Abstract] [Full Text]
|
|
|
|
|
|
L. T. van Elst, F. G. Woermann, L. Lemieux, P. J. Thompson, and M. R. Trimble Affective aggression in patients with temporal lobe epilepsy: A quantitative MRI study of the amygdala Brain, February 1, 2000; 123(2): 234 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bernasconi, A. Bernasconi, F. Andermann, F. Dubeau, W. Feindel, and D. C. Reutens Entorhinal cortex in temporal lobe epilepsy: A quantitative MRI study Neurology, June 1, 1999; 52(9): 1870 - 1870. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Mitchell, G. D. Jackson, R. M. Kalnins, M. M. Saling, G. J. Fitt, R. D. Ashpole, and S. F. Berkovic Anterior temporal abnormality in temporal lobe epilepsy: A quantitative MRI and histopathologic study Neurology, January 1, 1999; 52(2): 327 - 327. [Abstract] [Full Text]
|
|
|
|
|
|
F. G Woermann, G. J Barker, K. D Birnie, H. J Meencke, and J. S Duncan Regional changes in hippocampal T2 relaxation and volume: a quantitative magnetic resonance imaging study of hippocampal sclerosis J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 656 - 664. [Abstract] [Full Text]
|
|
|
|
|
|
G. D. Jackson, A. M. McIntosh, R. S. Briellmann, and S. F. Berkovic Hippocampal sclerosis studied in identical twins Neurology, July 1, 1998; 51(1): 78 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Watson, C. R. Jack Jr, and F. Cendes Volumetric Magnetic Resonance Imaging: Clinical Applications and Contributions to the Understanding of Temporal Lobe Epilepsy Arch Neurol, December 1, 1997; 54(12): 1521 - 1531. [Abstract] [PDF]
|
|
|
|
|
|
W. Van Paesschen, T. Revesz, and J. S Duncan Corpora amylacea in hippocampal sclerosis J. Neurol. Neurosurg. Psychiatry, October 1, 1997; 63(4): 513 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Goldstein, A. S. Harvey, M. Duchowny, P. Jayakar, N. Altman, T. Resnick, B. Levin, P. Dean, and L. Alvarez Preoperative Clinical, EEG, and Imaging Findings Do Not Predict Seizure Outcome Following Temporal Lobectomy in Childhood J Child Neurol, November 1, 1996; 11(6): 445 - 450. [Abstract] [PDF]
|
|
|
|
|
|
M. D. Holmes, C. B. Dodrill, A. J. Wilensky, L. M. Ojemann, and G. A. Ojemann Unilateral Focal Preponderance of Interictal Epileptiform Discharges as a Predictor of Seizure Origin Arch Neurol, March 1, 1996; 53(3): 228 - 232. [Abstract] [PDF]
|
|
|
|
|
|
S. R. Benbadis, N. K. So, M. A. Antar, G. H. Barnett, and H. H. Morris The Value of PET Scan (and MRI and Wada Test) in Patients With Bitemporal Epileptiform Abnormalities Arch Neurol, November 1, 1995; 52(11): 1062 - 1068. [Abstract] [PDF]
|
|
|
|
|
|
R. L. Gilmore, M. D. Childress, C. Leonard, R. Quisling, S. Roper, S. Eisenschenk, and M. Mahoney Hippocampal Volumetrics Differentiate Patients With Temporal Lobe Epilepsy and Extratemporal Lobe Epilepsy Arch Neurol, August 1, 1995; 52(8): 819 - 824. [Abstract] [PDF]
|
|
|
|
|
|
C. Adam, M. Baulac, J.-M. Saint-Hilaire, J. Landau, O. Granat, and D. Laplane Value of Magnetic Resonance Imaging-Based Measurements of Hippocampal Formations in Patients With Partial Epilepsy Arch Neurol, February 1, 1994; 51(2): 130 - 138. [Abstract] [PDF]
|
|
|
|
|
|
R. Kuzniecky, S. Burgard, E. Faught, R. Morawetz, and A. Bartolucci Predictive Value of Magnetic Resonance Imaging in Temporal Lobe Epilepsy Surgery Arch Neurol, January 1, 1993; 50(1): 65 - 69. [Abstract] [PDF]
|
|
|
|
|
|
M. Manford, Y. M. Hart, J. W. A. S. Sander, and S. D. Shorvon The National General Practice Study of Epilepsy: The Syndromic Classification of the International League Against Epilepsy Applied to Epilepsy in a General Population Arch Neurol, August 1, 1992; 49(8): 801 - 808. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
