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NEUROLOGY 1990;40:1888
© 1990 American Academy of Neurology

Constant relationships between force, phosphate concentration, and pH in muscles with differential fatigability

M. W. Weiner, MD, R. S. Moussavi, PhD, A. J. Baker, PhD, M. D. Boska, PhD and R. G. Miller, MD

Magnetic Resonance Unit (Drs. Weiner, Baker, and Boska), Veterans Administration Medical Center, and the Departments of Medicine and Radiology (Drs. Weiner, Baker, and Boska) and Neurology (Drs. Moussavi and Miller), University of California, San Francisco, and the Children's Hospital of San Francisco (Drs. Moussavi and Miller), San Francisco, CA.

We examined the relationships between muscle force and both phosphate and hydrogen ion concentrations in muscles with differential fatigability and in different types of exercise. We measured force and 31phosphorus nuclear magnetic resonance spectra from the tibialis anterior (a slow-contracting, fatigue resistant, postural leg muscle) during a sustained maximum contraction (anaerobic exercise) and during intermittent contractions (aerobic exercise). We observed similar relationships between the decline in muscle force during fatigue and changes in both phosphate and hydrogen ion concentrations during both aerobic and anaerobic exercise in tibialis anterior. Furthermore, these relationships were similar to those previously observed in the adductor pollicis. The demonstration of constant relationships between muscle contraction force and metabolism under different exercise conditions and in muscles of different function supports the view that both phosphate and hydrogen ions are important regulatory factors in the fatigue of human muscle.

Address correspondence and reprint requests to Dr. Michael W. Weiner, Magnetic Resonance Unit (11M), VA Medical Center, 4150 Clement Street, San Francisco, CA 94121.

Supported by grants from the Muscular Dystrophy Association (to Robert G. Miller), and National Institutes of Health (DK-33293) and Veterans Administration Medical Research Service Merit Review grants (to Michael W. Weiner).

Received January 27, 1989. Accepted for publication in final form May 1, 1990.




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