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Sensorineural hearing loss

A reversible effect of valproic acid

Department of Medicine (Neurology) (Drs. Armon and Shin), Duke University Medical Center, and the Neurodiagnostic Center (E. Brown, S. Carwile, P. Miller, and Dr. Shin), Department of Veterans Affairs Medical Center, Durham, NC.

We report 2 patients over the age of 70 who, while on valproate (VPA) for complex partial seizures, developed sensorineural hearing loss. Following discontinuation of VPA for nonaudiologic reasons, the patients reported improved hearing which was confirmed by audiometry. These findings represent VPA-induced sensorineural hearing loss, possibly in preexisting presbycusis.

Address correspondence and reprint requests to Dr. Cheolsu Shin, Neurodiagnostic Center, VA Medical Center, 508 Fulton Street, Durham, NC 27705.

Received April 4, 1990. Accepted for publication in final form May 22, 1990.

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