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NEUROLOGY 1990;40:492
© 1990 American Academy of Neurology

Successful treatment of acquired pendular elliptical nystagmus in multiple sclerosis with isoniazid and base-out prisms

S. Traccis, MD, G. Rosati, MD, M. F. Monaco, MD, I. Aiello, MD and V. Agnetti, MD

Neurological Clinic, Sassari University, Sassari, Italy.

We treated 3 multiple sclerosis patients who had pendular nystagmus with isoniazid (800 to 1,000 mg/d). Isoniazid abolished the nystagmus and relieved oscillopsia in 2 patients but was ineffective in the 3rd in whom the nystagmus was damped with convergence and vision improved with converging (base-out) prisms.

Address correspondence and reprint requests to Dr. Sebastiano Traccis, Clinica Neurologica, Viale S. Pietro, 10,07100 Sassari, Italy

Supported in part by grants from the C.N.R., M.P.I., and A.I.S. Regione Autonoma della Sardegna.

Received May 3,1988. Accepted for publication in final form August 21,1989.




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