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NEUROLOGY 1990;40:1140
© 1990 American Academy of Neurology

Effectiveness of sodium valproate in the treatment of Sydenham's chorea

Azhar S. Daoud, MRCP, Mohammed Zaki, MRCP(I), Raad Shakir, FRCP and Qusay Al-Saleh, MRCP(I)

Department of Paediatrics (Drs. Daoud, Zaki, and Al-Saleh), Farwania Hospital, and the Department of Neurology (Dr. Shakir), Faculty of Medicine, Kuwait University, Kuwait.

We treated 15 children with Sydenham's chorea with sodium valproate at a dose of 15 to 20 mg/kg/d. In 13 of them the chorieform movements disappeared within 1 week of therapy. The remaining 2 had incomplete response. Two patients relapsed; 1 of them responded to the reintroduction of valproate. The mean duration of treatment was 6.7 weeks. We observed no major side effects. This study strongly suggests that valproate is an effective drug in the treatment of Sydenham's chorea.

Address correspondence and reprint requests to Dr. Azhar S. Daoud, Department of Paediatrics, Farwania Hospital, PO Box 17517, Khaldiya, Code 72456 Kuwait.

Received July 10, 1989. Accepted for publication in final form December 28, 1989.




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