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Neuropsychological effects of carbamazepine and phenytoin

A reanalysis

Regional Epilepsy Center (Dr. Dodrill). University of Washington School of Medicine, Seattle, WA; and the Department of Neurology (Dr. Troupin), Louisiana State University, New Orleans, LA.

We previously reported that carbamazepine had fewer adverse neuropsychological effects than phenytoin, but it is now clear that our patients had much higher phenytoin than carbamazepine serum levels. When persons with high initial phenytoin levels were excluded, the statistical significance of all neuropsychological differences between the drugs disappeared.

Address correspondence and reprint requests to Dr. Carl B. Dodrill, Regional Epilepsy Center, Haborview Medical Center, Seattle, WA 98104.

Supported by grants NS 24823 and NS 17111 awarded by the National Institute of Neurological Disorders and Stroke, PHSDHHS. Ciba-Geigy assisted in the support of the original investigation. Warner-Lambert provided partial support of several research projects currently under way at the Regional Epilepsy Center in Seattle.

Received May 15, 1990. Accepted for publication in final form September 26, 1990.

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