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Brain and spinal cord hemorrhage in long-term survivors of malignant pediatric brain tumors

A possible late effect of therapy

Departments of Neurology (Dr. Allen). Pediatrics (Dr. Allen), Pathology (Drs. Miller and Budzilovich), and Neurosurgery (Dr. Epstein), NYU Medical Center, New York, NY.

Three children with malignant primary CNS tumors treated with craniospinal radiotherapy developed intraparenchymal hemorrhages a median of 5 years following therapy in sites distant from the primary tumor. Radical surgical procedures disclosed fresh and old hematoma, gliosis, and necrosis in all 3 patients and an aggregation of abnormal microscopic blood vessels in two. No tumor was found. All 3 patients remain in long-term (>10 years) continuous remission.

Address correspondence and reprint requests to Dr. Jeffrey C. Allen, NYU Medical Center, 550 First Avenue, New York, NY 10016.

Received April 26, 1990. Accepted for publication in final form June 25, 1990.

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