HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Griffin, D. E. Articles by Cornblath, D. R. Search for Related Content PubMed PubMed Citation Articles by Griffin, D. E. Articles by Cornblath, D. R.

Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic disease

Departments of Neurology and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.

We measured the levels of interferon- (IFN-) and neopterin in the serum and cerebrospinal fluid of 121 human immunodeficiency virus-seropositive (HIV +) and 62 -seronegative (HIV –) individuals evaluated for neurologic disease. CSF levels of IFN- and serum and CSF levels of neopterin were higher in HIV + than in HIV– individuals. Patients with HIV– related meningitis and with opportunistic CNS infections had higher serum neopterin levels than HIV+ asymptomatic individuals. CSF levels of IFN- were slightly higher in CSF of HIV + individuals in all groups (0.31 ± 0.03 U/ml) than in HIV– individuals (0.12 ± 0.03). CSF levels of neopterin were similar in HIV+ asymptomatic individuals (6.9 ± 0.7 nmol/l) and HIV– individuals (5.9 ± 1.1), but were elevated in those HIV– infected individuals with neurologic disease, particularly patients with HIV– associated meningitis (72.1 ± 13.3 nmol/l), opportunistic CNS infections (36 ± 9.1), and inflammatory demyelinating polyneuropathies (32.4 ± 17.2). Levels of neopterin correlated positively with levels of soluble interleukin 2 receptor and soluble CD8, 2 additional indicators of immune activation. In the absence of neurologic disease, levels of IFN- and neopterin in both serum and CSF were stable for up to 4 years after seroconversion. These data suggest that increased CSF neopterin is associated with HIV-associated neurologic disease.

Address correspondence and reprint requests to Dr. Diane E. Griffin, Meyer 6-181, The Johns Hopkins Hospital. Baltimore, MD 21205.

Supported by grants NS26643. AI72634, NS23639, and RR00722 from the National Institutes of Health.

Received April 20, 1990. Accepted for publication in final form June 22,1990.

This article has been cited by other articles:

				S. Hu, H. Ali, W. S. Sheng, L. C. Ehrlich, P. K. Peterson, and C. C. Chao Gp-41-Mediated Astrocyte Inducible Nitric Oxide Synthase mRNA Expression: Involvement of Interleukin-1beta Production by Microglia J. Neurosci., August 1, 1999; 19(15): 6468 - 6474. [Abstract] [Full Text] [PDF]

				D. Hariharan, S. D. Douglas, B. Lee, J.-P. Lai, D. E. Campbell, and W.-Z. Ho Interferon-gamma Upregulates CCR5 Expression in Cord and Adult Blood Mononuclear Phagocytes Blood, February 15, 1999; 93(4): 1137 - 1144. [Abstract] [Full Text] [PDF]

				C. D. Katsetos, J. E. Fincke, A. Legido, H. W. Lischner, J.-P. de Chadarevian, E. M. Kaye, C. D. Platsoucas, and E. L. Oleszak Angiocentric CD3+ T-Cell Infiltrates in Human Immunodeficiency Virus Type 1-Associated Central Nervous System Disease in Children Clin. Vaccine Immunol., January 1, 1999; 6(1): 105 - 114. [Abstract] [Full Text] [PDF]

				N. Sacktor, X. Liu, M. Popescu, K. Marder, Y. Stern, and R. Mayeux Serum Neopterin Level Predicts HIV-Related Mortality but Not Progression to AIDS or Development of Neurological Disease in Gay Men and Parenteral Drug Users Arch Neurol, July 1, 1995; 52(7): 676 - 679. [Abstract] [PDF]

				Diagnostic and Therapeutic Technology Assessment (DATTA) JAMA, June 3, 1992; 267(21): 2948 - 2952. [PDF]

				K. D. Kieburtz, L. G. Epstein, H. A. Gelbard, and J. T. Greenamyre Excitotoxicity and Dopaminergic Dysfunction in the Acquired Immunodeficiency Syndrome Dementia Complex: Therapeutic Implications Arch Neurol, December 1, 1991; 48(12): 1281 - 1284. [Abstract] [PDF]