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Human Cortical Physiology Unit, Human Motor Control Section, Medical Neurology Branch (Drs. Fuhr, Cohen, and Hallett), and Office of the Clinical Director (Dr. Wassermann), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
We studied the effects of transcranial magnetic stimulation of the motor cortex on ipsilateral upper extremity muscles in six normal men. Stimulation had inhibitory and excitatory effects on the muscles during voluntary activation. Transient inhibition, an ipsilateral silent period (ISP), occurred in all muscles tested, often without any preceding excitatory response. Motor evoked potentials (MEPs) occurred ipsilaterally in the proximal muscles of some subjects. Ipsilateral MEPs and ISPs were delayed relative to the MEPs evoked by the same stimulus in the corresponding contralateral muscles. The excitability of the alpha motoneuron pool, assessed during the period of the ISP by eliciting H-reflexes, showed no change, suggesting that ipsilateral inhibition acts at a level above the alpha motoneuron. Connections from motor cortex to ipsilateral muscles could be via the corpus callosum and contralateral hemisphere or via purely ipsilateral pathways.
Address correspondence and reprint requests to Dr. Eric Wassermann, Building 10, Room 5N226, National Institutes of Health, Bethesda, MD 20892.
Supported by the Swiss National Science Foundation (Dr. Fuhr).
Published in part in Society for Neuroscience Abstracts 1990;16:243.
Received January 15, 1991. Accepted for publication in final form May 3, 1991.
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