Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morris, J. C.
Right arrow Articles by Berg, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morris, J. C.
Right arrow Articles by Berg, L.
NEUROLOGY 1991;41:469
© 1991 American Academy of Neurology

Very mild Alzheimer's disease

Informant-based clinical, psychometric, and pathologic distinction from normal aging

J. C. Morris, MD, D. W. McKeel, Jr., MD, M. Storandt, PhD, E. H. Rubin, MD, PhD, J. L. Price, PhD, E. A. Grant, PhD, M. J. Ball, MD and L. Berg, MD

Departments of Neurology and Neurosurgery (Neurology) (Drs. Morris, Storandt, and Berg), Pathology (Drs. Morris and McKeel), Psychology (Dr. Storandt), Psychiatry (Dr. Rubin), Anatomy and Neurobiology (Dr. Price), and the Division of Biostatistics (Dr. Grant), Washington University, St. Louis, MO; the Departments of Pathology, Clinical Neurological Sciences, and Psychiatry (Dr. Ball), University of Western Ontario, London, ON, Canada; and the Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO.

We compare clinicopathologic data from 10 subjects identified in the very mild stage of senile dementia of the Alzheimer type with findings from similar studies in four cognitively normal subjects. We based the diagnosis of very mild dementia in the 10 subjects on informant reports and the judgment of experienced clinicians. Deficits of some psychometric measures of memory, language, and speeded psychomotor performance were observed for these subjects. The histologic markers of Alzheimer's disease, including neurofibrillary tangles and both the "diffuse" and classic subtypes of senile plaques, were present in the neocortex in all 10 subjects but essentially were absent in the four controls. These findings indicate that even "questionable" dementia can be diagnostic for Alzheimer's disease. Furthermore, because truly normal aging may be unaccompanied by neocortical senile plaques and neurofibrillary tangles, the presence of these lesions should suggest the possibility of clinically undetected Alzheimer's disease.

Address correspondence and reprint requests to Dr. John C. Morris, Memory and Aging Project, Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110.

Supported by NIA grants AG05681, AG03991, and AG03047; the Norman J. Stupp Foundation (St. Louis); and the Atkinson Charitable Foundation (Toronto).

Presented in part at the 40th annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.

Received May 23, 1990. Accepted for publication in final form October 2, 1990.




This article has been cited by other articles:


Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
M. Schmitter-Edgecombe, J. T. Howard, S. P. Pavawalla, L. Howell, and A. Rueda
Multidyad Memory Notebook Intervention for Very Mild Dementia: A Pilot Study
American Journal of Alzheimer's Disease and Other Dementias, October 1, 2008; 23(5): 477 - 487.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
S. E. O'Bryant, S. C. Waring, C. M. Cullum, J. Hall, L. Lacritz, P. J. Massman, P. J. Lupo, J. S. Reisch, R. Doody, and for the Texas Alzheimer's Research Consortium
Staging Dementia Using Clinical Dementia Rating Scale Sum of Boxes Scores: A Texas Alzheimer's Research Consortium Study
Arch Neurol, August 1, 2008; 65(8): 1091 - 1095.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
F. W. Unverzagt, Sujuan Gao, K. A. Lane, C. Callahan, A. Ogunniyi, O. Baiyewu, O. Gureje, K. S. Hall, and H. C. Hendrie
Mild Cognitive Dysfunction: An Epidemiological Perspective With an Emphasis on African Americans
J Geriatr Psychiatry Neurol, December 1, 2007; 20(4): 215 - 226.
[Abstract] [PDF]

Home page
 NeurologyHome page
J. E. Dunn, S. Weintraub, A. M. Stoddard, and S. Banks
Serum {alpha}-tocopherol, concurrent and past vitamin E intake, and mild cognitive impairment
Neurology, February 27, 2007; 68(9): 670 - 676.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Storandt, E. A. Grant, J. P. Miller, and J. C. Morris
Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
Neurology, August 8, 2006; 67(3): 467 - 473.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
V Isella, L Villa, A Russo, R Regazzoni, C Ferrarese, and I M Appollonio
Discriminative and predictive power of an informant report in mild cognitive impairment
J. Neurol. Neurosurg. Psychiatry, February 1, 2006; 77(2): 166 - 171.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
W. R. Markesbery, F. A. Schmitt, R. J. Kryscio, D. G. Davis, C. D. Smith, and D. R. Wekstein
Neuropathologic Substrate of Mild Cognitive Impairment
Arch Neurol, January 1, 2006; 63(1): 38 - 46.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. M. Dannhauser, Z. Walker, T. Stevens, L. Lee, M. Seal, and S. S. Shergill
The functional anatomy of divided attention in amnestic mild cognitive impairment
Brain, June 1, 2005; 128(6): 1418 - 1427.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. E. Galvin, K. K. Powlishta, K. Wilkins, D. W. McKeel Jr, C. Xiong, E. Grant, M. Storandt, and J. C. Morris
Predictors of Preclinical Alzheimer Disease and Dementia: A Clinicopathologic Study
Arch Neurol, May 1, 2005; 62(5): 758 - 765.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Bao, D. Lei, Y. Du, K. K. Ohlemiller, A. L. Beaudet, and L. W. Role
Requirement of Nicotinic Acetylcholine Receptor Subunit {beta}2 in the Maintenance of Spiral Ganglion Neurons during Aging
J. Neurosci., March 23, 2005; 25(12): 3041 - 3045.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
K. Meguro, M. Shimada, S. Yamaguchi, I. Sano, H. Inagaki, M. Matsushita, Y. Sekita, and E. Mori
Neuropsychosocial Features of Very Mild Alzheimer's Disease (CDR 0.5) and Progression to Dementia in a Community: The Tajiri Project
J Geriatr Psychiatry Neurol, December 1, 2004; 17(4): 183 - 189.
[Abstract] [PDF]

Home page
 JNMHome page
D. H.S. Silverman
Brain 18F-FDG PET in the Diagnosis of Neurodegenerative Dementias: Comparison with Perfusion SPECT and with Clinical Evaluations Lacking Nuclear Imaging
J. Nucl. Med., April 1, 2004; 45(4): 594 - 607.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
G. Devi, J. Williamson, F. Massoud, K. Anderson, Y. Stern, D. P. Devanand, and R. Mayeux
A Comparison of Family History of Psychiatric Disorders Among Patients With Early- and Late-Onset Alzheimer's Disease
J Neuropsychiatry Clin Neurosci, February 1, 2004; 16(1): 57 - 62.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. M. McMahon, S. S. Araki, E. A. Sandberg, P. J. Neumann, and G. S. Gazelle
Cost-Effectiveness of PET in the Diagnosis of Alzheimer Disease
Radiology, August 1, 2003; 228(2): 515 - 522.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J Tian, R S Bucks, J Haworth, and G Wilcock
Neuropsychological prediction of conversion to dementia from questionable dementia: statistically significant but not yet clinically useful
J. Neurol. Neurosurg. Psychiatry, April 1, 2003; 74(4): 433 - 438.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Mapstone, T. M. Steffenella, and C. J. Duffy
A visuospatial variant of mild cognitive impairment: Getting lost between aging and AD
Neurology, March 11, 2003; 60(5): 802 - 808.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. P. Salmon, R. G. Thomas, M. M. Pay, A. Booth, C. R. Hofstetter, L. J. Thal, and R. Katzman
Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals
Neurology, October 8, 2002; 59(7): 1022 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. K. Powlishta, D. D. Von Dras, A. Stanford, D. B. Carr, C. Tsering, J. P. Miller, and J. C. Morris
The clock drawing test is a poor screen for very mild dementia
Neurology, September 24, 2002; 59(6): 898 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
D. H.S. Silverman and G. W. Small
Prompt Identification of Alzheimer's Disease With Brain PET Imaging of a Woman With Multiple Previous Diagnoses of Other Neuropsychiatric Conditions
Am J Psychiatry, September 1, 2002; 159(9): 1482 - 1488.
[Full Text] [PDF]

Home page
 NeurologyHome page
F. W. Unverzagt, S. Gao, O. Baiyewu, A. O. Ogunniyi, O. Gureje, A. Perkins, C. L. Emsley, J. Dickens, R. Evans, B. Musick, et al.
Prevalence of cognitive impairment: Data from the Indianapolis Study of Health and Aging
Neurology, November 13, 2001; 57(9): 1655 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T. Ohnishi, H. Matsuda, T. Tabira, T. Asada, and M. Uno
Changes in Brain Morphology in Alzheimer Disease and Normal Aging: Is Alzheimer Disease an Exaggerated Aging Process?
AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1680 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series B: Psychological Sciences and Social ScienceHome page
K. Meguro, M. Shimada, S. Yamaguchi, J. Ishizaki, A. Yamadori, and Y. Sekita
A 5-Year Retrospective Examination of Cognitive Screening Test Stages in Normal Older Adults and Patients With Alzheimer's Disease: The Tajiri Project
J. Gerontol. B. Psychol. Sci. Soc. Sci., September 1, 2001; 56(5): P314 - 318.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
J. L. Price, A. I. Ko, M. J. Wade, S. K. Tsou, D. W. McKeel, and J. C. Morris
Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease
Arch Neurol, September 1, 2001; 58(9): 1395 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. C. Morris, M. Storandt, J. P. Miller, D. W. McKeel, J. L. Price, E. H. Rubin, and L. Berg
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Arch Neurol, March 1, 2001; 58(3): 397 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. Bozoki, B. Giordani, J. L. Heidebrink, S. Berent, and N. L. Foster
Mild Cognitive Impairments Predict Dementia in Nondemented Elderly Patients With Memory Loss
Arch Neurol, March 1, 2001; 58(3): 411 - 416.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. J. Buccafusco and A. V. Terry Jr.
Multiple Central Nervous System Targets for Eliciting Beneficial Effects on Memory and Cognition
J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 438 - 446.
[Abstract] [Full Text]

Home page
 JNMHome page
D. H.S. Silverman and M. E. Phelps
Evaluating Dementia Using PET: How Do We Put into Clinical Perspective What We Know to Date?
J. Nucl. Med., November 1, 2000; 41(11): 1929 - 1932.
[Full Text] [PDF]

Home page
 NeurologyHome page
F. A. Schmitt, D. G. Davis, D. R. Wekstein, C. D. Smith, J. W. Ashford, and W. R. Markesbery
""Preclinical"" AD revisited: Neuropathology of cognitively normal older adults
Neurology, August 8, 2000; 55(3): 370 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. F. Elias, A. Beiser, P. A. Wolf, R. Au, R. F. White, and R. B. D'Agostino
The Preclinical Phase of Alzheimer Disease: A 22-Year Prospective Study of the Framingham Cohort
Arch Neurol, June 1, 2000; 57(6): 808 - 813.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. C. Janssen, M. Hall, N. C. Fox, R. J. Harvey, J. Beck, A. Dickinson, T. Campbell, J. Collinge, P. L. Lantos, L. Cipolotti, et al.
Alzheimer's disease due to an intronic presenilin-1 (PSEN1 intron 4) mutation: A clinicopathological study
Brain, May 1, 2000; 123(5): 894 - 907.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series B: Psychological Sciences and Social ScienceHome page
J. C. Mundt, D. M. Freed, and J. H. Greist
Lay Person-Based Screening for Early Detection of Alzheimer's Disease: Development and Validation of an Instrument
J. Gerontol. B. Psychol. Sci. Soc. Sci., May 1, 2000; 55(3): P163 - P170.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. T. Tschanz, K. A. Welsh-Bohmer, I. Skoog, N. West, M. C. Norton, B. W. Wyse, R. Nickles, and J. C. S. Breitner
Dementia diagnoses from clinical and neuropsychological data compared: The Cache County study
Neurology, March 28, 2000; 54(6): 1290 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Ganguli, H. H. Dodge, P. Chen, S. Belle, and S. T. DeKosky
Ten-year incidence of dementia in a rural elderly US community population: The MoVIES Project
Neurology, March 14, 2000; 54(5): 1109 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
G. Devi, R. Ottman, M.-X. Tang, K. Marder, Y. Stern, and R. Mayeux
Familial Aggregation of Alzheimer Disease Among Whites, African Americans, and Caribbean Hispanics in Northern Manhattan
Arch Neurol, January 1, 2000; 57(1): 72 - 77.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
A. Kluger, S. H. Ferris, J. Golomb, M. S. Mittelman, and B. Reisberg
Neuropsychological Prediction of Decline to Dementia in Nondemented Elderly
J Geriatr Psychiatry Neurol, December 1, 1999; 12(4): 168 - 179.
[Abstract] [PDF]

Home page
 NeurologyHome page
G. Devi, R. Ottman, M. Tang, K. Marder, Y. Stern, B. Tycko, and R. Mayeux
Influence of APOE genotype on familial aggregation of AD in an urban population
Neurology, September 1, 1999; 53(4): 789 - 789.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. P. Goldman, J. D. Baty, V. D. Buckles, S. Sahrmann, and J. C. Morris
Motor dysfunction in mildly demented AD individuals without extrapyramidal signs
Neurology, September 1, 1999; 53(5): 956 - 956.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. Kuzis, L. Sabe, C. Tiberti, F. Dorrego, and S. E. Starkstein
Neuropsychological correlates of apathy and depression in patients with dementia
Neurology, April 1, 1999; 52(7): 1403 - 1403.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
R. C. Petersen, G. E. Smith, S. C. Waring, R. J. Ivnik, E. G. Tangalos, and E. Kokmen
Mild Cognitive Impairment: Clinical Characterization and Outcome
Arch Neurol, March 1, 1999; 56(3): 303 - 308.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Andersen, H. Nielsen, A. Lolk, J. Andersen, I. Becker, and P. Kragh-Sorensen
Incidence of very mild to severe dementia and Alzheimer's disease in Denmark: The Odense Study
Neurology, January 1, 1999; 52(1): 85 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. J. Dwork, E. S. Susser, J. Keilp, C. Waniek, D. Liu, M. Kaufman, Z. Zemishlany, and I. Prohovnik
Senile Degeneration and Cognitive Impairment in Chronic Schizophrenia
Am J Psychiatry, November 1, 1998; 155(11): 1536 - 1543.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
L. Berg, D. W. McKeel Jr, J. P. Miller, M. Storandt, E. H. Rubin, J. C. Morris, J. Baty, M. Coats, J. Norton, A. M. Goate, et al.
Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease: Relation of Histologic Markers to Dementia Severity, Age, Sex, and Apolipoprotein E Genotype
Arch Neurol, March 1, 1998; 55(3): 326 - 335.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
E. H. Rubin, M. Storandt, J. P. Miller, D. A. Kinscherf, E. A. Grant, J. C. Morris, and L. Berg
A Prospective Study of Cognitive Function and Onset of Dementia in Cognitively Healthy Elders
Arch Neurol, March 1, 1998; 55(3): 395 - 401.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
D. M A Mann
Molecular biology's impact on our understanding of aging
BMJ, October 25, 1997; 315(7115): 1078 - 1081.
[Full Text]

Home page
 ScienceHome page
J. H. Morrison and P. R. Hof
Life and Death of Neurons in the Aging Brain
Science, October 17, 1997; 278(5337): 412 - 419.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. I. Levey
Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease
PNAS, November 26, 1996; 93(24): 13541 - 13546.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Gomez-Isla, J. L. Price, D. W. McKeel Jr., J. C. Morris, J. H. Growdon, and B. T. Hyman
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer''s Disease
J. Neurosci., July 15, 1996; 16(14): 4491 - 4500.
[Abstract] [Full Text] [PDF]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
J. B. Norton and J. C. Morris
Obtaining consent for autopsy in dementia research: The Memory and Aging Project experience
American Journal of Alzheimer's Disease and Other Dementias, July 1, 1996; 11(4): 2 - 6.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
H. A. Crystal, D. Dickson, M. Sliwinski, D. Masur, A. Blau, and R. B. Lipton
Associations of Status and Change Measures of Neuropsychological Function With Pathologic Changes in Elderly, Originally Nondemented Subjects
Arch Neurol, January 1, 1996; 53(1): 82 - 87.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
P. Giannakopoulos, P. R. Hof, A.-S. Giannakopoulos, F. R. Herrmann, J.-P. Michel, and C. Bouras
Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Very Old Patients
Arch Neurol, December 1, 1995; 52(12): 1150 - 1159.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
M. Sano, D. P. Devanand, M. Richards, L. W. Miller, K. Marder, K. Bell, G. Dooneief, F. W. Bylsma, G. Lafleche, M. Albert, et al.
A Standardized Technique for Establishing Onset and Duration of Symptoms of Alzheimer's Disease
Arch Neurol, October 1, 1995; 52(10): 961 - 966.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
G. A. Gates, R. K. Karzon, P. Garcia, J. Peterein, M. Storandt, J. C. Morris, and J. P. Miller
Auditory Dysfunction in Aging and Senile Dementia of the Alzheimer's Type
Arch Neurol, June 1, 1995; 52(6): 626 - 634.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. Kaskie and M. Storandt
Visuospatial Deficit in Dementia of the Alzheimer Type
Arch Neurol, April 1, 1995; 52(4): 422 - 425.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
L. M. Bierer, P. R. Hof, D. P. Purohit, L. Carlin, J. Schmeidler, K. L. Davis, and D. P. Perl
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Arch Neurol, January 1, 1995; 52(1): 81 - 88.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
D. Galasko, L. A. Hansen, R. Katzman, W. Wiederholt, E. Masliah, R. Terry, L. R. Hill, P. Lessin, and L. J. Thal
Clinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias
Arch Neurol, September 1, 1994; 51(9): 888 - 895.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. T. Becker, F. Boiler, O. L. Lopez, J. Saxton, K. L. McGonigle, and Alzheimer Research Program
The Natural History of Alzheimer's Disease: Description of Study Cohort and Accuracy of Diagnosis
Arch Neurol, June 1, 1994; 51(6): 585 - 594.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
E. S. Paykel, C. Brayne, F. A. Huppert, C. Gill, C. Barkley, E. Gehlhaar, L. Beardsall, D. M. Girling, P. Pollitt, and D. O'Connor
Incidence of Dementia in a Population Older Than 75 Years in the United Kingdom
Arch Gen Psychiatry, April 1, 1994; 51(4): 325 - 332.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
M. D. Lindner, D. D. Gordon, J. M. Miller, P. N. Tariot, K. D. McDaniel, R. W. Hamill, P. S. DiStefano, and R. Loy
Increased Levels of Truncated Nerve Growth Factor Receptor in Urine of Mildly Demented Patients With Alzheimer's Disease
Arch Neurol, October 1, 1993; 50(10): 1054 - 1058.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. H. Price, H. Gurvit, S. Weintraub, C. Geula, E. Leimkuhler, and M. Mesulam
Neuropsychological Patterns and Language Deficits in 20 Consecutive Cases of Autopsy-Confirmed Alzheimer's Disease
Arch Neurol, September 1, 1993; 50(9): 931 - 937.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
R. J. Killiany, M. B. Moss, M. S. Albert, T. Sandor, J. Tieman, and F. Jolesz
Temporal Lobe Regions on Magnetic Resonance Imaging Identify Patients With Early Alzheimer's Disease
Arch Neurol, September 1, 1993; 50(9): 949 - 954.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. Golomb, M. J. de Leon, A. Kluger, A. E. George, C. Tarshish, and S. H. Ferris
Hippocampal Atrophy in Normal Aging: An Association With Recent Memory Impairment
Arch Neurol, September 1, 1993; 50(9): 967 - 973.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
L. Berg, D. W. McKeel Jr, J. P. Miller, J. Baty, and J. C. Morris
Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older
Arch Neurol, April 1, 1993; 50(4): 349 - 358.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
E. H. Rubin, M. Storandt, J. P. Miller, E. A. Grant, D. A. Kinscherf, J. C. Morris, and L. Berg
Influence of Age on Clinical and Psychometric Assessment of Subjects With Very Mild or Mild Dementia of the Alzheimer Type
Arch Neurol, April 1, 1993; 50(4): 380 - 383.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
E. LaBarge, D. S. Smith, L. Dick, and M. Storandt
Agraphia in Dementia of the Alzheimer Type
Arch Neurol, November 1, 1992; 49(11): 1151 - 1156.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
P. R. Hof, L. M. Bierer, D. P. Perl, A. Delacourte, L. Buee, C. Bouras, and J. H. Morrison
Evidence for Early Vulnerability of the Medial and Inferior Aspects of the Temporal Lobe in an 82-Year-Old Patient With Preclinical Signs of Dementia: Regional and Laminar Distribution of Neurofibrillary Tangles and Senile Plaques
Arch Neurol, September 1, 1992; 49(9): 946 - 953.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
T. Sandor, F. Jolesz, J. Tieman, R. Kikinis, K. Jones, and M. Albert
Comparative Analysis of Computed Tomographic and Magnetic Resonance Imaging Scans in Alzheimer Patients and Controls
Arch Neurol, April 1, 1992; 49(4): 381 - 384.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by AAN Enterprises, Inc.