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NEUROLOGY 1991;41:508
© 1991 American Academy of Neurology

Clinical and electrographic effects of acute anticonvulsant withdrawal in epileptic patients

David A. Marks, MD, Amiram Katz, MD, Richard Scheyer, MD and Susan S. Spencer, MD

Department of Neurology, Yale University School of Medicine, New Haven, CT.

We retrospectively investigated the effects of acute antiepileptic drug (AED) withdrawal on seizure symptomatology—including frequency, clinical features, and electrical onset—by studying 35 patients during evaluation for epilepsy surgery. The highest risk for both partial and secondary generalized seizures occurred during absent or subtherapeutic, and not during rapidly falling, AED levels. AED withdrawal had minimal effect on clinical symptomatology or electrographic onset.

Address correspondence and reprint requests to Dr. Susan S. Spencer, Yale University School of Medicine, 333 Cedar Street, LCI 702, New Haven, CT 06510.

Received June 20, 1990. Accepted for publication in final form October 3, 1990.




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