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NEUROLOGY 1991;41:828
© 1991 American Academy of Neurology

Chronic inflammatory demyelinating polyradiculoneuropathy of childhood

Treatment with high-dose intravenous immunoglobulin

Vettaikorumakankav V. Vedanarayanan, MD, Raymond S. Kandt, MD, Darrell V. Lewis, Jr., MD and G. Robert DeLong, MD

Division of Pediatric Neurology, Department of Pediatrics, Duke University Medical Center, Durham, NC.

We treated four children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with high-dose intravenous immunoglobulin (IVIG). All patients received 400 mg/kg of IVIG a day for 5 days during relapses, and one patient received additional periodic infusions of 400 mg/kg. All patients showed excellent recovery of motor strength following each relapse that was treated with IVIG. Compared with plasmapheresis (which was used to treat relapses earlier), recovery of function with IVIG treatments was similar, and in two patients it was superior, to plasmapheresis. There were no side effects with IVIG treatments as compared with plasmapheresis with which two children had infection of central lines with Staphylococcus epidermidis, one had profuse bleeding from accidental extrusion of a central line, and one had multiple episodes of major venous thromboses. High-dose IVIG was a safe and effective adjunctive therapy for childhood CIDP in these four patients.

Address correspondence and reprint requests to Dr. Vettaikorumakankav V. Vedanarayanan, Division of Neuromuscular Diseases, Johns Hopkins Hospital, 5-119 Meyer Building, 600 North Wolfe Street, Baltimore, MD 21205.

Received June 29, 1990. Accepted for publication in final form November 27, 1990.




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