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Neuro-ophthalmologic signs of AIDS

50 patients

Department of Neurology, Los Angeles County/University of Southern California Medical Center, Los Angeles, CA.

In 50 hospitalized patients with acquired immunodeficiency syndrome, signs of central eye movement limitation (28 cases) were most common. Peripheral eye movement limitations (18), abnormalities of vision (18), and abnormal spontaneous eye movements (15) occurred with about equal frequency. Meningitis (17), usually due to lymphoma (8) or Cryptococcus (8), was the usual cause of peripheral nervous System involvement, while toxoplasmosis (18) was more common than lymphoma (4) or presumed viral causes (8) in producing CNS dysfunction. The midbrain and pretectal (8) were affected about as often as the pontine tegmentum (9), but rostral brainstem lesions appeared to be the result of toxoplasmosis (4) or lymphoma (3), whereas a viral etiology was the presumed cause of most caudal stem involvement.

Address correspondence and reprint requests to Dr. James R. Keane, 1200 North State Street, Los Angeles, CA 90033.

Received September 20, 1990. Accepted for publication in final form November 27, 1990.

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