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Selegiline (deprenyl) treatment and death of nigral neurons in Parkinson's disease

Departments of Neurology (J.O. Rinne and U.K. Rinne) and Pathology (M. Röyttä), University of Turku, Turku, Finland; and the Department of Pathology (L. Paljärvi and J. Rummukainen), University of Kuopio, Kuopio, Finland.

We studied the effect of selegiline (deprenyl) treatment on the number of Lewy bodies and neuron counts in the substantia nigra in patients with Parkinson's disease (PD). The number of medial nigral neurons was greater and the number of Lewy bodies fewer in those PD patients who had been treated with selegiline in combination with levodopa as compared with patients who had received levodopa alone. This suggests that selegiline treatment may retard the death of nigral neurons, but alternative explanations, such as the reduction of levodopa dosage in selegiline-treated patients, are possible.

Address correspondence and reprint requests to Dr. Juha O. Rinne, Department of Neurology, University of Turku, SF-20520 Turku, Finland.

Supported by a grant from the Medical Research Council of the Academy of Finland.

Received September 7, 1990. Accepted for publication in final form November 14, 1990.

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