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NEUROLOGY 1991;41:869
© 1991 American Academy of Neurology

Behavioral state-specific changes in human hippocampal theta activity

K. J. Meador, MD, J. L. Thompson, MS, D. W. Loring, PhD, A. M. Murro, MD, D. W. King, MD, B. B. Gallagher, MD, PhD, G. P. Lee, PhD, J. R. Smith, MD and H. F. Flanigin, MD

Departments of Neurology and Surgery (Neurosurgery), Medical College of Georgia, Augusta, GA.

Although there has been extensive examination of the behavioral and physiologie correlates of hippocampal theta activity in animals, the human literature consists of a single case study. We investigated the differential effects of four behavioral states on human hippocampal theta activity in 16 epilepsy surgery patients. Behavioral conditions included resting eyes closed (RC), resting eyes open (RO), eyes open with auditory word activation (AW), and eyes open with visuospatial activation (VS). Hippocampal theta activity decreased during both RO and VS compared to both RC and AW. There were reciprocal changes in delta activity. Comparisons of RO to VS and of RC to AW were nonsignificant. The result demonstrate state-specific changes in human hippocampal theta and are consistent with the animal literature that relates hippocampal theta to sensorimotor integration and forebrain volitional mechanisms.

Address correspondence and reprint requests to Dr. Kimford J. Meador, Section of Behavioral Neurology, Department of Neurology, Medical College of Georgia, Augusta, GA 30912.

Supported in part by NIH/NIA grant # K08 AG00314 and by the Medical College of Georgia Research Institut.

Presented in part at the 42nd annual meeting of the American Academy of Neurology, Miami, FL, April 1990, and at the Second International Cleveland Clinic Epilepsy Symposium, Cleveland, OH, June 1990.

Received August 30, 1990. Accepted for publication in final form November 30, 1990.




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