| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Neurology (Drs. Lippa, Cohen, Smith, and Drachman), and Neuropathology (Drs. Lippa and Smith), University of Massachusetts Medical Center, Worcester, MA.
We describe the clinical, radiologic, neuropsychological, and neuropathologic features of a 69-year-old man with a 3-year history of progressive transcortical expressive aphasia. Neuropsychological testing showed progressive dysfunction of expressive language. Neuropathologic examination demonstrated focal cortical degeneration involving the left superior frontal gyrus, with swollen achromasic neurons and no evidence of Alzheimer's disease, Pick's disease, Creutzfeldt-Jakob disease, Lewy-body disease, or other dementing disorders. This case adds to the known heterogeneity of the underlying pathology of patients with primary progressive aphasia.
Address correspondence and reprint requests to Dr. Carol F. Lippa, Department of Neurology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.
Received September 28, 1990. Accepted for publication in final form November 26, 1990.
This article has been cited by other articles:
|
|
 |
|
  A. Kertesz, R. D. Fealey, B. M. Keegan, and J. E. Parisi A 74-year-old woman with progressive right-hand tremor and inability to use her right side Neurology, October 27, 2009; 73(17): 1399 - 1405. [Full Text] [PDF]
|
|
|
|
|
|
P. McMonagle, M. Blair, and A. Kertesz Corticobasal degeneration and progressive aphasia Neurology, October 24, 2006; 67(8): 1444 - 1451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Josephs, J. R. Duffy, E. A. Strand, J. L. Whitwell, K. F. Layton, J. E. Parisi, M. F. Hauser, R. J. Witte, B. F. Boeve, D. S. Knopman, et al. Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech Brain, June 1, 2006; 129(6): 1385 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Le Rhun, F. Richard, and F. Pasquier Natural history of primary progressive aphasia Neurology, September 27, 2005; 65(6): 887 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zadikoff and A. E. Lang Apraxia in movement disorders Brain, July 1, 2005; 128(7): 1480 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Nestor, N. L. Graham, T. D. Fryer, G. B. Williams, K. Patterson, and J. R. Hodges Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula Brain, November 1, 2003; 126(11): 2406 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-M. Mesulam Primary Progressive Aphasia -- A Language-Based Dementia N. Engl. J. Med., October 16, 2003; 349(16): 1535 - 1542. [Full Text] [PDF]
|
|
|
|
|
|
N. L. Graham, T. Bak, K. Patterson, and J. R. Hodges Language function and dysfunction in corticobasal degeneration Neurology, August 26, 2003; 61(4): 493 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Clark, M. F. Mendez, E. Farag, and H. V. Vinters Clinicopathologic Case Report: Progressive Aphasia in a 77-Year-Old Man J Neuropsychiatry Clin Neurosci, May 1, 2003; 15(2): 231 - 238. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kertesz and D. G. Munoz Primary progressive aphasia: A review of the neourobiology of a common presentation of Pick complex American Journal of Alzheimer's Disease and Other Dementias, January 1, 2002; 17(1): 30 - 36. [Abstract] [PDF]
|
|
|
|
|
|
D. W. Dickson Neuropathology of Pick's disease Neurology, June 12, 2001; 56(90004): S16 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shafiq, L. Nee, J. Grafman, N. Tresser, V.M.-Y. Lee, J.Q. Trojanowski, and C.F. Lippa Frontotemporal dementia: Report of a familial case Neurology, June 12, 2001; 56(90004): S31 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kertesz, P. Martinez-Lage, W. Davidson, and D. G. Munoz The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia Neurology, November 14, 2000; 55(9): 1368 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P S Mathuranath, J. H Xuereb, T. Bak, and J. R Hodges Corticobasal ganglionic degeneration and/or frontotemporal dementia? A report of two overlap cases and review of literature J. Neurol. Neurosurg. Psychiatry, March 1, 2000; 68(3): 304 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Grimes, A. E. Lang, and C. B. Bergeron Dementia as the most common presentation of cortical-basal ganglionic degeneration Neurology, December 1, 1999; 53(9): 1969 - 1969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Soliveri, D. Monza, D. Paridi, D. Radice, M. Grisoli, D. Testa, M. Savoiardo, and F. Girotti Cognitive and magnetic resonance imaging aspects of corticobasal degeneration and progressive supranuclear palsy Neurology, August 1, 1999; 53(3): 502 - 502. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Kertesz Frontotemporal Dementia, Pick Disease, and Corticobasal Degeneration: One Entity or 3? 1 Arch Neurol, November 1, 1997; 54(11): 1427 - 1429. [Abstract] [PDF]
|
|
|
|
|
|
P. N. Cooper, M. Jackson, G. Lennox, J. Lowe, and D. M. A. Mann {tau} Ubiquitin, and {alpha}B-Crystallin Immunohistochemistry Define the Principal Causes of Degenerative Frontotemporal Dementia Arch Neurol, October 1, 1995; 52(10): 1011 - 1015. [Abstract] [PDF]
|
|
|
|
|
|
B. H. Price, H. Gurvit, S. Weintraub, C. Geula, E. Leimkuhler, and M. Mesulam Neuropsychological Patterns and Language Deficits in 20 Consecutive Cases of Autopsy-Confirmed Alzheimer's Disease Arch Neurol, September 1, 1993; 50(9): 931 - 937. [Abstract] [PDF]
|
|
|
|
|
|
H. Karbe, A. Kertesz, and M. Polk Profiles of Language Impairment in Primary Progressive Aphasia Arch Neurol, February 1, 1993; 50(2): 193 - 201. [Abstract] [PDF]
|
|
|
|
|
|
C. Confavreux, B. Croisile, P. Garassus, G. Aimard, and M. Trillet Progressive Amusia and Aprosody Arch Neurol, September 1, 1992; 49(9): 971 - 976. [Abstract] [PDF]
|
|
|
|
|
|
R. J. Caselli and C. R. Jack Jr Asymmetric Cortical Degeneration Syndromes: A Proposed Clinical Classification Arch Neurol, July 1, 1992; 49(7): 770 - 780. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
