HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vandesteen, A. Articles by Zegers, D. Search for Related Content PubMed PubMed Citation Articles by Vandesteen, A. Articles by Zegers, D.

Synaptic effects of halogenated anesthetics on short-latency SEP

Service de Neurologie (Drs. Nogueira, Mavroudakis, and Zegers de Beyl), Service d'Anesthésiologie (Drs. Vandesteen and Defevrimont), and Unité de Recherche sur le Cerveau (Dr. Brunko), Université Libre de Bruxelles, Brussels, Belgium.

We evaluated the effects of different stable end-tidal concentrations of isoflurane, enflurane, or halothane on short-latency somatosensory evoked potentials recorded during general anesthesia. Isoflurane and enflurane significantly enhanced the P22 over the pre-central scalp, whereas the parietal N20 amplitude did not increase. The P22 increase did not occur with halothane, which indicates that the P22 changes are a specific effect of certain anesthetics, probably related to their influence on synaptic events. At the subcortical level, isoflurane and enflurane increased significantly the N13 peak latency and decreased the interval between the N13 peak and P14 peak, which implicates interference with synaptic transmission at the spinal level. Halothane had no effect at the spinal level. All three anesthetics significantly increased the central conduction time.

Address correspondence and reprint requests to Dr. D. Zegers de Beyl, Service de Neurologie, Hôpital Erasme, Route de Lennik, 808, B-1070 Bruxelles, Belgium.

Presented in part at the 42nd annual meeting of the American Academy of Neurology, Miami Beach, FL, April 1990.

Received September 17, 1990. Accepted for publication in final form November 27, 1990.

This article has been cited by other articles:

				S. Westeren-Punnonen, H. Ypparila-Wolters, J. Partanen, K. Nieminen, A. Hyvarinen, and H. Kokki Somatosensory Evoked Potentials by Median Nerve Stimulation in Children During Thiopental/Sevoflurane Anesthesia and the Additive Effects of Ketoprofen and Fentanyl Anesth. Analg., September 1, 2008; 107(3): 799 - 805. [Abstract] [Full Text] [PDF]

				A.-M. Huotari, M. Koskinen, K. Suominen, S. Alahuhta, R. Remes, K. M. Hartikainen, and V. Jantti Evoked EEG patterns during burst suppression with propofol Br. J. Anaesth., January 1, 2004; 92(1): 18 - 24. [Abstract] [Full Text] [PDF]