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NEUROLOGY 1991;41:923
© 1991 American Academy of Neurology

Repeat thymectomy in chronic refractory myasthenia gravis

Robert G. Miller, MD, Amy Filler-Katz, RN, Dobri Kiprov, MD and Ralph Roan, MD

Departments of Neurology, Immunology, and Surgery, Children's Hospital of San Francisco and the University of California at San Francisco, San Francisco, CA.

Encouraged by recent results with "extended" thymectomy in the treatment of myasthenia gravis, we carried out repeat thymectomy in six patients with chronic, refractory disease who did not initially have extended thymectomy. All were completely disabled with longstanding myasthenia. Initial thymectomy (four transsternal, one transcervical, and one substernal) was carried out at a mean of 8.9 years previously (range, 5 to 18). There was no residual thymus observed with CT, but at repeat thymectomy, residual thymic tissue was present in five of six patients. Five patients significantly improved and four returned to full-time work. Mean prednisone dose declined from 51 mg to 18 mg/d, and mean pyridostigmine dose fell from 1,290 mg to 415 mg/d. No patient to date has had a complete remission. These results suggest that repeat thymectomy may benefit some patients with chronic disabling myasthenia gravis, especially when it is uncertain from a review of the operative report whether all thymic tissue was removed at the initial thymectomy.

Address correspondence and reprint requests to Dr. Robert G. Miller, Department of Neurology, Childrens Hospital of San Francisco, 3700 California Street, East Campus, Room 545, San Francisco, CA 94118.

Supported by a grant from the Muscular Dystrophy

Received August 8, 1990. Accepted for publication in final form November 11, 1990.




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