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NEUROLOGY 1991;41:925
© 1991 American Academy of Neurology

Cytotoxic activity in plasma from patients with amyotrophic lateral sclerosis

K. Overgaard, MD, L. Werdelin, MD PhD, H. Sørensen, MD PhD, P. Mogensen, MD and G. Boysen, MD PhD

Departments of Clinical Immunology (Drs. Overgaard and Sørensen) and of Neurology (Drs. Werdelin and Boysen), Rigshospitalet, and the Department of Neurology (Dr. Mogensen), Hvidovre Hospital, Copenhagen, Denmark.

The present study evaluates an assay of cytotoxic effect of plasma from patients with amyotrophic lateral sclerosis. Plasma from 20 recently diagnosed ALS patients induced hemolysis of normal red blood cells with a significantly greater intensity than that of normal controls. After at least 1 month of treatment with prednisone and azathioprine, the hemolytic activity of ALS plasma was reduced but was still higher than that of control plasma.

Address correspondence and reprint requests to Dr. Karsten Overgaard, Department of Neurology, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.

Supported by the Foundation for Experimental Research in Neurology and the Foundation of Svend Aage Wacherhausen.

Received May 25, 1990. Accepted for publication in final form November 26, 1990.






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