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NEUROLOGY 1991;41:1006
© 1991 American Academy of Neurology

Mild cognitive impairment in the elderly

Predictors of dementia

Charles Flicker, PhD, Steven H. Ferris, PhD; and and Barry Reisberg, MD

Aging and Dementia Research Center, New York University Medical Center, New York, NY.

We conducted full diagnostic evaluations, including a comprehensive cognitive assessment battery, of a group of 32 elderly subjects with a clinically identified mild cognitive impairment and a group of 32 age-matched and education-matched normal subjects. The mildly impaired subjects performed significantly more poorly than the controls on tests of recent memory, remote memory, language function, concept formation, and visuospatial praxis. Follow-up evaluations of cognitive status 2 years later revealed clinically detectable cognitive decline relative to baseline in 23 (72%) of the mildly impaired subjects. Several of the objective psychological tests accurately discriminated at baseline between the decliners and nondecliners in the mildly impaired group. Among the 20 mildly impaired subjects with no complicating conditions, 16 exhibited cognitive deterioration between baseline and follow-up. These results suggest that most elderly subjects with mild cognitive deficits, as determined by clinical evaluation and objective psychological testing, will manifest the progressive mental deterioration characteristic of dementia and that psychometric predictors can be used to distinguish between benign and more significant underlying disorders in mildly impaired elderly subjects.

Address correspondence and reprint requests to Dr. Charles Flicker, Dept. Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, New York, NY 10016.

Supported in part by Grant #MH 40410 from the National Institute of Mental Health and by Grant #AG 03051 from the National Institute on Aging.

Received July 30, 1990. Accepted for publication in final form December 27, 1990.




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Hippocampal Atrophy in Normal Aging: An Association With Recent Memory Impairment
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[Abstract] [PDF]

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C. Flicker, S. H. Ferris, and B. Reisberg
A Two-Year Longitudinal Study of Cognitive Function in Normal Aging and Alzheimer's Disease
J Geriatr Psychiatry Neurol, April 1, 1993; 6(2): 84 - 96.
[Abstract] [PDF]


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