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Cerebrospinal fluid protein and opening pressure in idiopathic intracranial hypertension (pseudotumor cerebri)

Departments of Neurology (Drs. Johnston and Corbett) and Ophthalmology (Dr. Corbett), University of Iowa Hospitals and Clinics, Iowa City, IA, and the Department of Medicine (Dr. Maxner), Dalhousie University, Halifax, Nova Scotia, Canada.

We studied the relationship between the CSF protein concentration and the degree of elevation of the CSF opening pressure in 177 patients with idiopathic intracranial hypertension (pseudotumor cerebri). There was no linear correlation between the CSF protein and opening pressure. In addition, low CSF protein (<20 mg/dl) was present in only 26% of the patients. Our findings fail to confirm previous reports of an inverse relationship between the CSF opening pressure and CSF protein as well as low CSF protein in these patients.

Address correspondence and reprint requests to Dr. Patricia K. Johnston, Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242.

Presented in part at the 42nd annual meeting of the American Academy of Neurology, Miami Beach, FL, May 1990.

Received October 2, 1990. Accepted for publication in final form December 27, 1990.

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