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Generalized peripheral neuropathy in a dental technician exposed to methyl methacrylate monomer

Department of Clinical Neurology (Drs. Donaghy and Rushworth), Radcliffe Infirmary, Oxford, and the Department of Neuropathology (Dr. Jacobs), Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

A 58-year-old dental prosthetic technician developed generalized sensorimotor peripheral neuropathy. Neurophysiologic studies showed a generalized sensorimotor neuropathy of axonal degeneration type. Examination of a sural nerve biopsy showed a moderately severe axonal neuropathy with loss of large myelinated fibers and unmyelinated axons. There was evidence of slow ongoing degeneration and considerable fiber regeneration. Electron microscopy showed increased numbers of filaments in a few fibers. These findings show resemblances to the nerve changes caused by another acrylic resin, acrylamide. We suggest that the neuropathy may have been caused by 30 years of occupational cutaneous and inhalational exposure to methyl methacrylate monomer since we excluded other recognized causes of neuropathy.

Address correspondence and reprint requests to Dr. M. Donaghy, Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX5 2HE, UK.

Received September 19, 1990. Accepted for publication in final form December 14, 1990.

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