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Two cases of neoplastic angioendotheliomatosis presenting with myelopathy

Hokuyukai Neurological Hospital (Drs. K. Hamada, T. Hamada, and Satoh), Department of Neurology (Drs. Tashiro and Katoh) and Pathology (Drs. Ogata and Nagashima), Hokkaido University School of Medicine, and National Sapporo Minami Hospital (Drs. Naganuma and Shima), Sapporo, Japan.

We describe two patients with autopsy-proven neoplastic angioendotheliomatosis (NAE) presenting only as a transverse myelopathy for 10 to 12 months, followed by disseminated intracranial manifestations. Postmortem examination disclosed a vasculocentric distribution of neoplastic cells in various organs that stained positively with B-lymphocyte-specific monoclonal antibody. These cases were unusual because they manifested as an isolated myelopathy for many months.

Address correspondence and reprint requests to Dr. Kohji Hamada, Hokuyukai Neurological Hospital, 4-30,2-jo 2-chome, 24-ken, Nishiku Sapporo, Hokkaido, 063 Japan.

Received March 28, 1990. Accepted for publication in final form December 27, 1990.

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