| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Multiple Sclerosis Clinic (Dr. Sadovnick, K. Eisen, and Dr. Paty), University Hospital-UBC Site and the Department of Medical Genetics (Dr. Sadovnick), University of British Columbia, Vancouver, BC; and Multiple Sclerosis Clinic (Dr. Ebers), University Hospital, University of Western Ontario, London, ON, Canada.
Between 1972 and 1988, 145 deaths occurred among 3,126 patients attending the Multiple Sclerosis (MS) Clinics in Vancouver, British Columbia (N = 1,583), and London, Ontario (N = 1,543). We could determine the exact cause of death in 82.1% of cases (119 of 145). Of the 119 patients for whom the cause of death was known, 56 deaths (47.1%) were directly attributed to complications of MS. Of the remaining 63 deaths, 18 (28.6%) were suicides, 19 (30.2%) were due to malignancy, 13 (20.6%) to an acute myocardial infarction, seven (11.1%) to stroke, and the remainder (9.5%) to miscellaneous causes, of which two may have been suicides. The proportion of suicides among MS deaths was 7.5 times that for the age-matched general population, and the proportion of MS deaths from malignancy was 0.67 times that for the age-matched general population. The proportion of deaths due to malignancy and stroke was the same for the MS patients and the age-matched general population.
Address correspondence and reprint requests to Dr. A.D. Sadovnick, Department of Medical Genetics, University of British Columbia, 226–6174 University Blvd., Vancouver, BC, V6T 1Z3, Canada.
Supported by the Multiple Sclerosis Society of Canada and the Molson Foundation. Dr. Sadovnick's personal support is, in part, from the Multiple Sclerosis Society of Canada, British Columbia Division.
Received October 26, 1990. Accepted for publication in final form January 28, 1991.
This article has been cited by other articles:
|
|
 |
|
  C. Smestad, L. Sandvik, and E. Celius Excess mortality and cause of death in a cohort of Norwegian multiple sclerosis patients Multiple Sclerosis, November 1, 2009; 15(11): 1263 - 1270. [Abstract] [PDF]
|
|
|
|
 |
|
 I. S. Haussleiter, M. Brune, and G. Juckel Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment Therapeutic Advances in Neurological Disorders, January 1, 2009; 2(1): 13 - 29. [Abstract] [PDF]
|
|
|
|
|
|
N Grytten Torkildsen, S. Lie, J. Aarseth, H Nyland, and K. Myhr Survival and cause of death in multiple sclerosis: results from a 50-year follow-up in Western Norway Multiple Sclerosis, November 1, 2008; 14(9): 1191 - 1198. [Abstract] [PDF]
|
|
|
|
 |
|
 C Hirst, R Swingler, D A S Compston, Y Ben-Shlomo, and N P Robertson Survival and cause of death in multiple sclerosis: a prospective population-based study J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 1016 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Ghaffar and A. Feinstein Multiple sclerosis and cannabis: A cognitive and psychiatric study Neurology, July 15, 2008; 71(3): 164 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lebrun, M. Debouverie, P. Vermersch, P. Clavelou, L. Rumbach, J. de Seze, S. Wiertlevski, G. Defer, O. Gout, F. Berthier, et al. Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis Multiple Sclerosis, April 1, 2008; 14(3): 399 - 405. [Abstract] [PDF]
|
|
|
|
|
|
E. Leray, S. Morrissey, J. Yaouanq, M. Coustans, E. Le Page, J. Chaperon, and G. Edan Long-term survival of patients with multiple sclerosis in West France Multiple Sclerosis, August 1, 2007; 13(7): 865 - 874. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Jefferies The neuropsychiatry of multiple sclerosis Adv. Psychiatr. Treat., May 1, 2006; 12(3): 214 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Holland and D. E. Northrop Young Adults With Multiple Sclerosis: Management in the Home Home Health Care Management Practice, April 1, 2006; 18(3): 186 - 195. [Abstract] [PDF]
|
|
|
|
 |
|
 C.H. Hawkes Are multiple sclerosis patients risk-takers? QJM, December 1, 2005; 98(12): 895 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P Falcone, A. Nappo, and B. Neuteboom Interferon Beta-1a Overdose in a Multiple Sclerosis Patient Ann. Pharmacother., November 1, 2005; 39(11): 1950 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Bronnum-Hansen, E Stenager, E Nylev Stenager, and N Koch-Henriksen Suicide among Danes with multiple sclerosis J. Neurol. Neurosurg. Psychiatry, October 1, 2005; 76(10): 1457 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Goldman Consensus Group The Goldman Consensus statement on depression in multiple sclerosis Multiple Sclerosis, June 1, 2005; 11(3): 328 - 337. [Abstract] [PDF]
|
|
|
|
|
|
R J Siegert and D A Abernethy Depression in multiple sclerosis: a review J. Neurol. Neurosurg. Psychiatry, April 1, 2005; 76(4): 469 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Rickards Depression in neurological disorders: Parkinson's disease, multiple sclerosis, and stroke J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(suppl_1): i48 - i52. [Full Text] [PDF]
|
|
|
|
|
|
L J Edwards and C S Constantinescu A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic Multiple Sclerosis, October 1, 2004; 10(5): 575 - 581. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Hjalgrim, S. Rasmussen, K. Rostgaard, N. M. Nielsen, N. Koch-Henriksen, L. Munksgaard, H. H. Storm, and M. Melbye Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis J Natl Cancer Inst, May 19, 2004; 96(10): 780 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Quesnel and A. Feinstein Multiple sclerosis and alcohol: a study of problem drinking Multiple Sclerosis, April 1, 2004; 10(2): 197 - 201. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Bronnum-Hansen, N. Koch-Henriksen, and E. Stenager Trends in survival and cause of death in Danish patients with multiple sclerosis Brain, April 1, 2004; 127(4): 844 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Pittock, W. T. Mayr, R. L. McClelland, N. W. Jorgensen, S. D. Weigand, J. H. Noseworthy, B. G. Weinshenker, and M. Rodriguez Change in MS-related disability in a population-based cohort: A 10-year follow-up study Neurology, January 13, 2004; 62(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B Patten, S. Fridhandler, C. A Beck, and L. M Metz Depressive symptoms in a treated multiple sclerosis cohort Multiple Sclerosis, December 1, 2003; 9(6): 616 - 620. [Abstract] [PDF]
|
|
|
|
|
|
P. O'Connor Key issues in the diagnosis and treatment of multiple sclerosis: An overview Neurology, September 24, 2002; 59(90063): S1 - 33. [Full Text]
|
|
|
|
|
|
A. Feinstein An examination of suicidal intent in patients with multiple sclerosis Neurology, September 10, 2002; 59(5): 674 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M-L Sumelahti, P J Tienari, J Wikstrom, T M Salminen, and M Hakama Survival of multiple sclerosis in Finland between 1964 and 1993 Multiple Sclerosis, August 1, 2002; 8(4): 350 - 355. [Abstract] [PDF]
|
|
|
|
|
|
L. B. Krupp and S. A. Rizvi Symptomatic therapy for underrecognized manifestations of multiple sclerosis Neurology, April 23, 2002; 58(90084): S32 - 39. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. K. Burt, S. Slavin, W. H. Burns, and A. M. Marmont Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood, February 1, 2002; 99(3): 768 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. DeSousa, R. H. Albert, and B. Kalman Cognitive impairments in multiple sclerosis: A review American Journal of Alzheimer's Disease and Other Dementias, January 1, 2002; 17(1): 23 - 29. [Abstract] [PDF]
|
|
|
|
 |
|
 J. H. Noseworthy, C. Lucchinetti, M. Rodriguez, and B. G. Weinshenker Multiple Sclerosis N. Engl. J. Med., September 28, 2000; 343(13): 938 - 952. [Full Text] [PDF]
|
|
|
|
|
|
E. U. Walther and R. Hohlfeld Multiple sclerosis: Side effects of interferon beta therapy and their management Neurology, November 1, 1999; 53(8): 1622 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Smeltzer and M. H. Lavietes Reliability of Maximal Respiratory Pressures in Multiple Sclerosis Chest, June 1, 1999; 115(6): 1546 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F Smith and C. L Darlington Recent developments in drug therapy for multiple sclerosis Multiple Sclerosis, April 1, 1999; 5(2): 110 - 120. [Abstract] [PDF]
|
|
|
|
|
|
N. Koch-Henriksen, H. Brønnum-Hansen, and E. Stenager Underlying cause of death in Danish patients with multiple sclerosis: results from the Danish Multiple Sclerosis Registry J. Neurol. Neurosurg. Psychiatry, July 1, 1998; 65(1): 56 - 59. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Miller, D. Bourdette, P. Ritvo, W. Stuart, and T. Vollmer The Neurologist's Perspective: What Do We Know and Where Do We Go? Neurorehabil Neural Repair, January 1, 1994; 8(3): 105 - 111. [Abstract] [PDF]
|
|
|
|
|
|
A. L. Berman and L. Samuel Suicide Among People with Multiple Sclerosis Neurorehabil Neural Repair, January 1, 1993; 7(2): 53 - 62. [Abstract] [PDF]
|
|
|
|
 |
|
 E. N. Stenager and E. Stenager Suicide and Patients With Neurologic Diseases: Methodologic Problems Arch Neurol, December 1, 1992; 49(12): 1296 - 1303. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
