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Glycine prodrug facilitates memory retrieval in humans

VA Medical Center and Georgetown University School of Medicine (Drs. Schwartz and Deutsch); George Washington University (Dr. Hashtroudi); Searle Research and Development (Dr. Herting); and VA Medical Center (Dr. Handerson), Washington, DC.

Modulation of glycine concentrations in the brain influences learning and memory functions in experimental animals. We administered Milacemide, a glycine prodrug, or placebo to young and older healthy adults, who performed a word-retrieval task. Milacemide administration increased the number of words retrieved and decreased the latency with which these words were retrieved for both young and older adults.

Address correspondence and reprint requests to Dr. S.I. Deutsch, Department of Veterans Affairs Medical Center, Chief, Psychiatry Service (116A), 50 Irving Street, N.W., Washington, DC 20422.

Supported by a grant from Searle Research and Development, Division of Searle, Skokie, IL, to Dr. Barbara Schwartz.

Received December 27, 1990. Accepted for publication in final form March 4, 1991.

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