NEUROLOGY 1991;41:1374
© 1991 American Academy of Neurology
Frontal lobe degeneration
Clinical, neuropsychological, and SPECT characteristics
B. L. Miller, MD,
J. L. Cummings, MD,
J. Villanueva-Meyer, MD,
K. Boone, PhD,
C. M. Mehringer, MD,
I. M. Lesser, MD and
I. Mena, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
The clinical, neuropsychological, and cerebral blood flow characteristics of eight patients with frontal lobe degeneration (FLD) were studied. Social withdrawal and behavioral disinhibition were the earliest and most common clinical presentations, and psychiatric symptoms typically preceded the onset of dementia by several years. Neuropsychological testing showed selective impairment of frontal and memory tasks with relative sparing of attention, language, and visuospatial skills. Single-photon emission computerized tomography demonstrated frontal and temporal hypoperfusion with relative sparing of parietal and occipital blood flow. Previous studies suggest that the neuropathologic findings in patients with FLD are varied; some demonstrate frontal gliosis, neuronal loss, and Pick bodies while others show only gliosis and neuronal loss.
Address correspondence and reprint requests to Dr. Bruce L. Miller, Department of Neurology B-4, Harbor-UCLA Medical Center, Torrance, CA 90509.
Supported by a Physician-Scientist-Award from the National Institute of Aging, USPHS A K11 G 00284, and a grant from the Mental Health Branch of the State of California.
Received July 16, 1990. Accepted for publication in final form February 6, 1991.
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