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NEUROLOGY 1991;41:1385
© 1991 American Academy of Neurology

The Libyan Creutzfeldt-Jakob disease focus in Israel

An epidemiologic evaluation

Nelly Zilber, D ès Sc, Esther Kahana, MD and Miriam Abraham, MPH

Neuroepidemiology Unit, Department of Neurology (Drs. Zilber and Kahana), Hadassah University Hospital, Jerusalem, Israel; the Department of Social Medicine (Dr. Zilber and M. Abraham), School of Public Health and Community Medicine, Jerusalem, Israel; INSERM (Dr. Zilber), U 169, Villejuif, France; and Neurology Unit (Dr. Kahana), Barzilai Medical Centre, Ashkelon, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel.

In a country-wide study of Creutzfeldt-Jakob disease (CJD) in Israel, we diagnosed 114 cases, among them 49 Libyan-born, with onset of their disease during the years 1963-1987. After age adjustment, the mean annual incidence rate per million population was 43 among Libyan-born and 0.9 in the rest of the population. Among Jews born in Egypt and Tunisia, neighboring countries of Libya, the adjusted rates were higher than in the other Israelis (3.5 and 2.3 per million, respectively). Among Libyan Jews, there was no association between incidence rate of CJD and age at immigration, ie, duration of exposure to hypothetical infectious factor in Libya. The percent of familial cases among Libyan Jews (41 to 47%) is one of the highest ever published. Genetic factors seem to be important for the high incidence of CJD among Libyan Jews.

Address correspondence and reprint requests to Dr. E. Kahana, Neurology Unit, Barzilai Medical Centre, Ashkelon, 78306, Israel.

Received December 21, 1990. Accepted for publication in final form February 28, 1991.




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