| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neuroepidemiology Unit (Drs. Kahana and Zilber), Department of Neurology, Hadassah University Hospital, Jerusalem; Neurology Unit (Dr. Kahana), Barzilai Medical Center, Ashkelon, and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba; the Department of Social Medicine (Dr. Zilber and M. Abraham), School of Public Health and Community Medicine, Hebrew University, Jerusalem, Israel; and INSERM (Dr. Zilber), U-169 Villejuif, France.
A focus of Creutzfeldt-Jakob disease is present in Israel among Jews born in Libya. The present study examines the clinical features in this particular group of patients. In a country-wide study of Creutzfeldt-Jakob disease, we identified 114 patients; 49 were Libyan immigrants, and 65 (three of whom had Libyan ancestors) were born in other countries. The clinical presentation and evolution of the disease is very similar in patients born in Libya and others without Libyan ancestors, but it tends to be more classical in the Libyan patients, with higher frequency of myoclonic jerks and periodic EEG and a progressive course of shorter duration. The Libyan patients tend to complain more often of headache, which is most probably an ethnic expression for depression and loss of concentration. There was no difference between the familial and nonfamilial cases.
Address correspondence and reprint requests to Dr. Esther Kahana, Neurology Unit, Barzilai Medical Center, Ashkelon, 78306, Israel.
Received December 21, 1990. Accepted for publication in final form February 28, 1991.
This article has been cited by other articles:
|
|
 |
|
  N. Ghoshal, I. Cali, R. J. Perrin, S. A. Josephson, N. Sun, P. Gambetti, and J. C. Morris Codistribution of Amyloid {beta} Plaques and Spongiform Degeneration in Familial Creutzfeldt-Jakob Disease With the E200K-129M Haplotype Arch Neurol, October 1, 2009; 66(10): 1240 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lee, H. Rosenmann, J. Chapman, P. B. Kingsley, C. Hoffmann, O. S. Cohen, E. Kahana, A. D. Korczyn, and I. Prohovnik Thalamo-striatal diffusion reductions precede disease onset in prion mutation carriers Brain, October 1, 2009; 132(10): 2680 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gambetti, Q. Kong, W. Zou, P. Parchi, and S. G Chen Sporadic and familial CJD: classification and characterisation Br. Med. Bull., June 1, 2003; 66(1): 213 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Taratuto, P. Piccardo, E. G. Reich, S. G. Chen, G. Sevlever, M. Schultz, A. A. Luzzi, M. Rugiero, G. Abecasis, M. Endelman, et al. Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease Neurology, February 12, 2002; 58(3): 362 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Mastrianni, S. Capellari, G. C. Telling, D. Han, P. Bosque, S. B. Prusiner, and S. J. DeArmond Inherited prion disease caused by the V210I mutation: Transmission to transgenic mice Neurology, December 26, 2001; 57(12): 2198 - 2205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.B. Prusiner Molecular Biology and Genetics of Prion Diseases Cold Spring Harb Symp Quant Biol, January 1, 1996; 61(0): 473 - 493. [Abstract] [PDF]
|
|
|
|
|
|
S. B. Prusiner Genetic and Infectious Prion Diseases Arch Neurol, November 1, 1993; 50(11): 1129 - 1153. [Abstract] [PDF]
|
|
|
|
 |
|
 J. M. Bertoni, P. Brown, L. G. Goldfarb, R. Rubenstein, and D. C. Gajdusek Familial Creutzfeldt-Jakob Disease (Codon 200 Mutation) With Supranuclear Palsy JAMA, November 4, 1992; 268(17): 2413 - 2415. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
