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*Deceased.
Department of Neurology (Dr. Kokmen), the Department of Health Sciences Research, Section of Clinical Epidemiology (Dr. Ballard and C.M. Beard), and the Department of Health Sciences Research, Section of Biostatistics (Dr. Offord), Mayo Clinic, Rochester, MN; and Neuroepidemiology Branch (Drs. Chandra and Schoenberg), NINDS, NIH, Bethesda, MD.
Using information on clinical risk factors provided through the medical record linkage system of the Rochester Epidemiology Project, we conducted a population-based case-control study of Alzheimer's disease (AD). During the period 1960 to 1974, we identified 415 newly diagnosed cases of AD among residents of Rochester, Minnesota, and matched one community control to each case based on age, sex, and duration of community medical record. We estimated odds ratios using conditional logistic regression for several potential clinical risk factors for AD. Among more than 20 clinical risk factors that were evaluated, the only statistically significant findings were for episodic depression, personality disorder, and hypertension.
Address correspondence and reprint requests to Dr. Emre Kokmen, Department of Neurology, Mayo Clinic, 200 SW First Street, Rochester, MN 55905.
Supported in part by grants AG06786 and AR30582 from the National Institutes of Health, Bethesda, MD. Dr. Ballard is supported in part by a career development award from the Merck, Sharp & Dohme/Society for Epidemiologic Research Clinical Epidemiology Fellowship Program.
Received August 7, 1990. Accepted for publication in final form February 28, 1991.
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