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Division of Neurology (Dr Rajput), Department of Pathology (Dra. Rozdilsky and Ang), and College of Medicine (Alex Rajput), University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Essential tremor (ET) is the most common pathologic tremor, but only eight cases have been studied pathologically. We report detailed clinical and neuropathologic studies of six additional patients. We did not find any neuropathologic lesions that might be specific for ET. Moreover, there were no abnormalities of the substantia nigra consistent with Parkinson's disease. The neuropathologic substrate of ET remains unknown.
Address correspondence and reprint requests to Dr. A.H. Rajput, Department of Medicine, Division of Neurology, Royal University Hospital, Saskatoon, Saskatchewan S7N OXO, Canada.
Supported by a grant from the Saskatchewan Parkinson's Disease Foundation.
Received November 13, 1990. Accepted for publication in final form February 15, 1991.
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