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NEUROLOGY 1991;41:1437
© 1991 American Academy of Neurology

Visual sensitivity to motion

Age-related changes and deficits in senile dementia of the Alzheimer type

Gary L. Trick, PhD and Scott E. Silverman, MS, MD

Department of Ophthalmology and Visual Sciences (Drs. Trick and Silverman), the Alzheimer's Disease Research Center (Dr. Trick), and the Department of Psychology (Dr. Trick), Washington University, St. Louis, MO.

To determine whether motion sensitivity varies with age, we measured motion discrimination in visual normals 25 to 80 years of age and found that motion thresholds increased linearly with age and were approximately two times higher in those 70 to 80 years old than in participants under thirty. This increase was not attributable to pupil size or retinal image distortion, but probably reflects neurodegeneration in the primary visual pathway. We compared the motion sensitivity of patients with senile dementia of the Alzheimer type (SDAT) with results from a subset of the visual normals of similar age. In SDAT patients, there were significant threshold elevations, which were more pronounced in the patients with more severe dementia. These findings confirm previous reports of visual system involvement in SDAT and indicate motion testing may reveal preclinical visual system involvement in SDAT.

Address correspondence and reprint requests to Dr. Gary L. Trick, Department of Ophthalmology, Box 8096, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110.

Supported in part by the Washington University Alzheimer's Disease Research Center Grant (5P50 AG05681), an Alzheimer's disease research grant from the State of Missouri (G.L.T.), and NEI grant R01 EY06046 (G.L.T.).

Portions of the material contained in this paper were presented at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO), Sarasota, FL, May 1990.

Received December 18, 1990. Accepted for publication in final form February 6, 1991.




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