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Baroreflexes in patients with diabetes mellitus

Department of Neurology, University of Minnesota, Minneapolis, MN.

We evaluated baroreflexes in 58 diabetic and 15 control subjects by determining the latency of response between the end of a Valsalva maneuver (VM) and points on the resultant blood pressure and heart rate (HR) response curves. Prolonged latencies indicative of sympathetic dysfunction were demonstrated in 44% to 88% of diabetic subjects. The results challenge the view that sympathetic dysfunction cannot be detected before parasympathetic abnormalities are manifest. Baroreflex latencies reflected sympathetic dysfunction early in the course of diabetes, some times in patients with normal HR responses to deep breathing and to a VM.

Address correspondence and reprint requests to Dr. William R. Kennedy, Box 187 UMHC, 420 Delaware Street SE, Minneapolis, MN 55455.

Supported by National Institutes of Health grant NS 26348.

Presented in part at the International Congress of EEG and Clinical Neurophysiology, Rio de Janeiro, Brazil, January 1990.

Received October 24, 1990. Accepted for publication in final form March 4, 1991.

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