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9p monosomy in a patient with Gilles de la Tourette's syndrome

Department of Pathology (Dr. Taylor), the Institute for Molecular Genetics (Drs. Taylor, Krizman, Greenberg, Fenwick, and Caskey); and the Departments of Neurology (Dr. Jankovic) and Pediatrics (Drs. Hayani, Steuber. and Greenberg), Baylor College of Medicine, Houston, TX.

Gilles de la Tourette's syndrome (GTS) is a genetic disorder characterized by multiple motor and vocal tics, obsessive-compulsive disorder, and attention-deficit disorder. Family studies support the presence of an autosomal dominant gene; however, to date, an assignment for the GTS locus has not been made. We present the case of a boy with GTS and a deletion of the terminal portion of the short arm of chromosome 9, del(9)(qter—p2304:).

Address correspondence and reprint requests to Dr. Linda Taylor, Baylor College of Medicine, Department of Pathology, One Baylor Plaza, Houston, TX 7703O.

Supported by the Baylor Cancer Cytogenetics Laboratory, the Tourette Syndronie Association, and the Baylor College of Medicine General Clinical Research Center at the Methodist Hospital (grant NIH 5 M01 RR00350).

Received November 15, 1990. Accepted for publication in final form February 13, 1991.

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