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Departments of Neurology (Drs. Phillips, Anderson, and Cox) and Neurosurgery (Dr. Torner), University of Virginia Health Sciences Center, Charlottesville, VA.
We conducted a study of the epidemiology of myasthenia gravis (MG) in four locations in central and western Virginia from 1970 through 1984. The population surveyed was 555,851 in 1984. A total of 73 new cases of MG occurred during the survey period, producing an overall average annual incidence rate of 9.1 per million. The point prevalence rate in 1980 was 13.4 per 100,000, and in 1984 it was 14.2. Approximately 15% of the population was black, and we found that incidence and prevalence rates for the black population were higher than the corresponding white population. When the population was subdivided into <50 and 50+ age groups, the incidence and prevalence were significantly higher in the older group. The rates we report here are higher than rates reported from any other locality. The reasons for the higher rates include optimal case identification, survey of a population with a higher incidence, and increasing aging of the population.
Address correspondence and reprint requests to Dr. Lawrence H. Phillips II, Department of Neurology, Box 394, University of Virginia Health Sciences Center, Charlottesville, VA 22908.
Drs. Anderson and Cox were supported by Joan Shapiro Research Fellowship Awards from the National Myasthenia Gravis Foundation.
Presented in part at the 38th annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.
Received December 16, 1991. Accepted for publication in final form March 3, 1992.
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