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Department of Neurology (Drs. Morgante, Di Rosa, and Di Perri), University of Messina; Italian Multicentre Study on Dementia, SMID Centre (Dr. Rocca), Florence; Mental Health Service (Dr. De Domenico), USL 41, Messina; Department of Statistical Sciences (Dr. Grigoletto), University of Padua; Department of Biostatistics and Epidemiology (Dr. Meneghini), Fidia Research Laboratories, Abano Terme; Department of Neurology (Drs. Reggio and Patti), University of Catania; and Department of Neurology (Drs. Savettieri and Castiglione), University of Palermo, Italy.
We investigated the prevalence of Parkinson's disease and other types of parkinsonism in a Sicilian population using a door-to-door two-phase approach. This design called for the administration of a brief screening instrument to all subjects who, on November 1, 1987, were residents of Terrasini (Palermo Province), Santa Teresa di Riva (Messina Province), and Riposto (Catania Province), Sicily (N = 24,496). Study neurologists using specified diagnostic criteria extensively investigated those subjects who screened positive. We found 63 subjects affected by Parkinson's disease, 21 with secondary parkinsonism, and seven with unspecified parkinsonism. The crude prevalence per 100,000 population was 371.5 for all types of parkinsonism and 257.2 for Parkinson's disease; for both entities, prevalence increased steeply with age and showed an inconsistent sex pattern. Our prevalence figures for Parkinson's disease are higher than those previously reported in Italy or elsewhere, which may be due, in part, to more complete case-ascertainment.
Address correspondence and reprint requests to Dr. F. Meneghini, Department of Biostatistics and Epidemiology, Fidia Research Laboratories, via Ponte della Fabbrica 3/A, 35031 Abano Terme (Padua), Italy.
Supported by the Assessorato alla Sanita della Regione Sicilia (Grant N 58P) and by Fidia Research Laboratories, Abano Terme, Italy
Presented in part at the 42nd annual meeting of the American Academy of Neurology, Miami Beach, FL, April 1990.
Received September 19, 1991. Accepted for publication in final form March 10, 1992.
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