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Multiple sclerosis with very late onset

Division of Neurology, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

Multiple sclerosis (MS) can present clinically after age 59, but only rarely. In a large MS population (N = 2,019), 0.6% of patients had their first symptom at age 60 or older. Of this group, six had clinically definite MS, two had laboratory-supported definite MS, and four had clinically probable MS. The onset at this age was characteristically a slow deterioration of motor function. Most (10 of 12) of these very late-onset patients had a progressive course of disease from onset.

Address correspondence and reprint requests to Dr. John P. Hooge, #702–1160 Burrard Street, Vancouver, BC, Canada V6Z 2E8.

Received October 10, 1991. Accepted for publication in final form March 10, 1992.

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