| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neurology, University School of Medicine, and Ospedale Maggiore, Novara, Italy.
In 25 normal subjects, we studied the EMG silent period following the magnetic motor evoked potential (MEP) when the target muscle was tonically contracted (post-MEP silent period [PMSPI). In the first dorsal interosseus muscle (FDI), PMSP duration increased in linear proportion to stimulus intensity, but not to the size of the preceding MEP. The PMSP was longer in hand and forearm muscles than in upper arm muscles. In the FDI, PMSP was longer than the peripheral silent period (PSP) even when multiple peripheral stimuli were used to get M responses whose twitch force was equivalent to that of MEPs. Weak magnetic stimuli evoked silent periods preceded by no MEP in several subjects. Spinal 
-motoneurons (-MNs) were partially inhibited during the first PMSP portion, but later this effect recovered. MEPs due to weak electrical stimuli to motor cortex were only slightly inhibited during the late PMSP. Segmental inhibitory loops evoked by the muscle twitch and inhibitory projections descending to -MNs from the cortex predominantly underlie earlier PMSP portions, but recurrent intracortical inhibition may also contribute. Later portions are predominantly due to other stimulus-related cerebral inhibitory or suppressing phenomena.
Address correspondence and reprint requests to Dr. Roberto Cantello, Clinica Neurologica, Ospedale Maggiore, 28100 Novara, Italy.
Presented in preliminary form at a meeting of the Italian Society of Clinical Neurophysiology, Siena, October 14–16, 1990.
Received December 10, 1991. Accepted for publication in final form March 31, 1992.
This article has been cited by other articles:
|
|
 |
|
  J. Shemmell, J. H. An, and E. J. Perreault The Differential Role of Motor Cortex in Stretch Reflex Modulation Induced by Changes in Environmental Mechanics and Verbal Instruction J. Neurosci., October 21, 2009; 29(42): 13255 - 13263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. van Kuijk, J. W. Pasman, H. T. Hendricks, M. J. Zwarts, and A. C. H. Geurts Predicting Hand Motor Recovery in Severe Stroke: The Role of Motor Evoked Potentials in Relation to Early Clinical Assessment Neurorehabil Neural Repair, January 1, 2009; 23(1): 45 - 51. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Vucic, G. A. Nicholson, and M. C. Kiernan Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis Brain, June 1, 2008; 131(6): 1540 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Frantseva, P. B. Fitzgerald, R. Chen, B. Moller, M. Daigle, and Z. J. Daskalakis Evidence for Impaired Long-Term Potentiation in Schizophrenia and Its Relationship to Motor Skill Leaning Cereb Cortex, May 1, 2008; 18(5): 990 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. J Daskalakis, B. K Christensen, P. B Fitzgerald, B. Moller, S. I Fountain, and R. Chen Increased cortical inhibition in persons with schizophrenia treated with clozapine J Psychopharmacol, March 1, 2008; 22(2): 203 - 209. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Szubski, M. Burtscher, and W. N. Loscher The effects of short-term hypoxia on motor cortex excitability and neuromuscular activation J Appl Physiol, December 1, 2006; 101(6): 1673 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vucic and M. C. Kiernan Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease Brain, September 1, 2006; 129(9): 2436 - 2446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liepert, C. Restemeyer, T. Kucinski, S. Zittel, and C. Weiller Motor Strokes: The Lesion Location Determines Motor Excitability Changes Stroke, December 1, 2005; 36(12): 2648 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kr. Pal, R. Hanajima, C. A. Gunraj, J.-Y. Li, A. Wagle-Shukla, F. Morgante, and R. Chen Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Interhemispheric Inhibition J Neurophysiol, September 1, 2005; 94(3): 1668 - 1675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. O Paradiso, D. I Cunic, C. A Gunraj, and R. Chen Representation of facial muscles in human motor cortex J. Physiol., August 15, 2005; 567(1): 323 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Varrasi, C. Civardi, C. Boccagni, M. Cecchin, R. Vicentini, F. Monaco, and R. Cantello Cortical excitability in drug-naive patients with partial epilepsy: A cross-sectional study Neurology, December 14, 2004; 63(11): 2051 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Civardi, R. Vicentini, G. Grugni, and R. Cantello Corticospinal Physiology in Patients With Prader-Willi Syndrome: A Transcranial Magnetic Stimulation Study Arch Neurol, October 1, 2004; 61(10): 1585 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L Pearce, T. S Miles, P. D Thompson, and M. A Nordstrom Responses of single motor units in human masseter to transcranial magnetic stimulation of either hemisphere J. Physiol., June 1, 2003; 549(2): 583 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. J. Daskalakis, B. K. Christensen, P. B. Fitzgerald, and R. Chen Transcranial Magnetic Stimulation: A New Investigational and Treatment Tool in Psychiatry J Neuropsychiatry Clin Neurosci, November 1, 2002; 14(4): 406 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cantello, R.A. L. Macdonell, M.A. King, M.R. Newton, J.M. Curatolo, D.C. Reutens, and S.F. Berkovic Prolonged cortical silent period after transcranial magnetic stimulation in generalized epilepsy Neurology, April 9, 2002; 58(7): 1135 - 1136. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. J. Daskalakis, B. K. Christensen, R. Chen, P. B. Fitzgerald, R. B. Zipursky, and S. Kapur Evidence for Impaired Cortical Inhibition in Schizophrenia Using Transcranial Magnetic Stimulation Arch Gen Psychiatry, April 1, 2002; 59(4): 347 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Civardi, C Boccagni, R Vicentini, L Bolamperti, R Tarletti, C Varrasi, F Monaco, and R Cantello Cortical excitability and sleep deprivation: a transcranial magnetic stimulation study J. Neurol. Neurosurg. Psychiatry, December 1, 2001; 71(6): 809 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Guerrini, P. Bonanni, A. Patrignani, P. Brown, L. Parmeggiani, P. Grosse, P. Brovedani, F. Moro, P. Aridon, R. Carrozzo, et al. Autosomal dominant cortical myoclonus and epilepsy (ADCME) with complex partial and generalized seizures: A newly recognized epilepsy syndrome with linkage to chromosome 2p11.1-q12.2 Brain, December 1, 2001; 124(12): 2459 - 2475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Gandevia Spinal and Supraspinal Factors in Human Muscle Fatigue Physiol Rev, October 1, 2001; 81(4): 1725 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A V Chistyakov, J F Soustiel, H Hafner, M Trubnik, G Levy, and M Feinsod Excitatory and inhibitory corticospinal responses to transcranial magnetic stimulation in patients with minor to moderate head injury J. Neurol. Neurosurg. Psychiatry, May 1, 2001; 70(5): 580 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sandbrink, N. A. Syed, M. D. Fujii, M. C. Dalakas, and M. K. Floeter Motor cortex excitability in stiff-person syndrome Brain, November 1, 2000; 123(11): 2231 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Taylor, G. M. Allen, J. E. Butler, and S. C. Gandevia Supraspinal fatigue during intermittent maximal voluntary contractions of the human elbow flexors J Appl Physiol, July 1, 2000; 89(1): 305 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cantello, M. Gianelli, C. Civardi, and R. Mutani Focal Subcortical Reflex Myoclonus: A Clinical and Neurophysiological Study Arch Neurol, February 1, 1997; 54(2): 187 - 196. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
