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Valproate acute administration, EEG epileptic abnormalities, and ammonemia

Center for Neuroactive Drugs, Institute of Neurophysiopathology of the University, and the Center for Cerebral Neurophysiology, National Council of Research, Genoa, Italy; and the Department of Psychiatry, State University of New York, Stony Brook, NY.

Acute, oral administration of 14.3 to 37.5 mg/kg magnesium valproate (peak serum concentrations, 65 to 139 µg/ml) increases spike-wave frequency at 2, 3, 4, and 5 hours postdrug, in the absence of hyperammonemia or significant correlations with ammonemia fluctuations. This observation suggests a direct role of valproate on neural activity.

Address correspondence and reprint requests to Professor Walter G. Sannita, Centro Parmaci Neuroattivi, Uipartimento di Scienze Motorie, Universita, Ospedale San Martino, viale Benedetto XV, I-16132 Genova, Italy.

Received November 1, 1991. Accepted for publication in final form March 12, 1992.