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NEUROLOGY 1992;42:2019
© 1992 American Academy of Neurology

Amyloidoma of the CNS.

Clinical and pathologic study

M. Cohen MD, D. Lanska MD, U. Roessmann MD, B. Karaman MD, E. Ganz MD, P. Whitehouse MD and P. Gambetti MD

Division of Neuropathology, Institute of Pathology (Drs. Cohen, Roessmann, and Gambetti), the Departments of Neuroradiology (Dr. Karaman) and Neurosurgery (Dr. Ganz), and the Alzheimer Center (Dr. Whitehouse), Case Western Reserve University, Cleveland, OH; and the Department of Neurology (Dr. Lanska), University of Kentucky Medical Center, Lexington, KY.

We report a 32-year-old man with a 4-year history of headaches, seizures, and dementia secondary to multifocal amyloidomas in the white matter. Immunohistochemical and electron microscopic analyses suggest that the amyloidomas resulted from processing of plasma-cell-derived amyloidogenic protein by microglial cells.

Address correspondence and reprint requests to Dr. Mark Cohen, Division of Neuropathology, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106.

Supported by NIH Merit Award AGNS08155, NIA ADRC AG-08012 and NINCDS NS14509, NIA AG00144, NIA ADRC AGO5144 and NIH CIDA K08-NS-015490.

Received January 8, 1992. Accepted for publication in final form March 26, 1992




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