NEUROLOGY 1992;42:303
© 1992 American Academy of Neurology
Clinical and electrophysiologic findings in chronic neuropathy of Lyme disease
Eric L. Logigian, MD and
Allen C. Steere, MD
Departments of Neurology (Dr. Logigian) and Rheumatology (Dr. Steere), New England Medical Center, Boston, MA.
We evaluated 25 patients with Lyme disease and chronic peripheral neuropathy. All had immunologic evidence of exposure to Borrelia burgdorferi and no other identifiable cause of neuropathy. Neuropathic symptoms began a median of 8 months (range, 0 to 165) after erythema migrans and had been present for a median of 12 months (range, 2 to 168) prior to evaluation. Twelve patients (48%) had generally symmetric distal, nonpainful pares-thesia, and another 12 (48%) had generally asymmetric radicular pain. One patient (4%) had asymptomatic neuropathy. The most common physical finding was multimodal sensory loss, which was observed in 13 patients (52%); weakness and hyporeflexia were less common. Motor or sensory nerve conduction was slightly slow in 16 patients (64%). The paresthesia group more often had abnormalities on physical examination and on nerve conduction testing than did the radicular group. In 75% to 80% of patients from both groups, however, needle examination showed denervation in paraspinal and limb muscles. Among 20 patients who underwent lumbar puncture, only one had a slight spinal fluid pleocytosis. Six months after treatment with intravenous ceftriaxone, 19 patients (76%) were clinically improved. We conclude that Lyme disease can be associated with a reversible, mild chronic axonal sensorimotor polyradiculoneuropathy or polyradiculopathy.
Address correspondence and reprint requests to Dr. Eric L. Logigian, Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.
Received March 21, 1991. Accepted for publication in final form July 30, 1991.
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