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Interrater reliability in the neuropathologic diagnosis of Alzheimer's disease

From Ludwig Boltzmann Institute of Clinical Neurobiology (Drs. Paulus, Bancher, and Jellinger), Vienna, Austria; and Department of Pathology (Dr. Paulus), Division of Neuropathology, University of Würzburg, Germany.

Three neuropathologists evaluated brain sections from 43 aged subjects for the presence of Alzheimer's disease. Moderate-to-substantial agreement was obtained. After discussion of disparate diagnoses, agreement was almost perfect for standardized and substantial for personal criteria. We conclude that reproducibility can be improved if diagnoses based on standardized criteria are discussed by at least two neuropathologists.

Address correspondence and reprint requests to Dr. Werner Paulus, Division of Neuropathology, Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, D-8700 Würzburg, Germany.

Received April 11, 1991. Accepted for publication in final form July 17, 1991.

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