HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rodriguez, M. Articles by Lindsley, M. D. Search for Related Content PubMed PubMed Citation Articles by Rodriguez, M. Articles by Lindsley, M. D.

Immunosuppression promotes CNS remyelination in chronic virus-induced demyelinating disease

Departments of Neurology (Dr. Rodriguez) and Immunology (Drs. Rodriguez and Lindsley), Mayo Medical School, Rochester, MN.

Immunosuppression using cyclophosphamide or anti-T cell monoclonal antibodies (mAbs) directed at CD4 or CD8 promoted remyelination of CNS axons in the spinal cords of mice infected chronically with Theiler's virus. Treatment with a mAb directed at class II major histocompability gene products did not increase the extent of CNS remyelination. Following immunosuppressive treatment, quantitative morphometry revealed a five- to sevenfold increase in new myelin synthesis. Proliferating nervous system cells were identified at the edges of remyelinated lesions by their incorporation of [³H]thymidine. CNS remyelination occurred in mice depleted of selected subsets of T lymphocytes despite the local persistence of viral antigen. These findings indicate that CNS remyelination occurs as a normal consequence of primary myelin injury, but factors associated with immune T cells somehow impair remyelination. Interference with the function of immune T cells enhances CNS remyelination by oligodendrocytes. Similar depletion of immune T cells may allow for enhanced remyelination in the CNS of patients with chronic multiple sclerosis.

Address correspondence and reprint requests to Dr. Moses Rodriguez, Department of Immunology, Mayo Clinic/Foundation, Rochester, MN 55905.

Supported by grants NS 24180 and CA-09127 from the National Institutes of Health and RG 1878-B1 and RG-2174-A-3 from the National Multiple Sclerosis Society.

Received May 31, 1991. Accepted for publication in final form July 24, 1991.

This article has been cited by other articles:

				D. R. Ure, T. E. Lane, M. T. Liu, and M. Rodriguez Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection Int. Immunol., May 1, 2005; 17(5): 569 - 579. [Abstract] [Full Text] [PDF]

				P. D. Murray, D. B. McGavern, S. Sathornsumetee, and M. Rodriguez Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis Brain, July 1, 2001; 124(7): 1403 - 1416. [Abstract] [Full Text] [PDF]

				J. H. Noseworthy, P. C. O'Brien, T. M. Petterson, J. Weis, L. Stevens, W. K. Peterson, D. Sneve, S. A. Cross, J. A. Leavitt, R. G. Auger, et al. A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis Neurology, June 12, 2001; 56(11): 1514 - 1522. [Abstract] [Full Text] [PDF]

				D. Mcgavern, K. Asakura, and M. Rodriquez Do Antibodies Stimulate Myelin Repair in Multiple Sclerosis? Neuroscientist, January 1, 1999; 5(1): 19 - 28. [Abstract] [PDF]

				K. D. Pavelko, B. G. M. van Engelen, and M. Rodriguez Acceleration in the Rate of CNS Remyelination in Lysolecithin-Induced Demyelination J. Neurosci., April 1, 1998; 18(7): 2498 - 2505. [Abstract] [Full Text] [PDF]

				A. Compston Remyelination in multiple sclerosis: a challenge for therapy: The 1996 European Charcot Foundation Lecture Multiple Sclerosis, April 1, 1997; 3(2): 51 - 70. [PDF]

				C. Lucchinetti, J. Noseworthy, and M. Rodriguez Promotion of endogeneous remyelination in Multiple Sclerosis Multiple Sclerosis, April 1, 1997; 3(2): 71 - 75. [Abstract] [PDF]

				B. G. van Engelen, K. D Pavelko, and M. Rodriguez Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination Multiple Sclerosis, April 1, 1997; 3(2): 76 - 79. [Abstract] [PDF]

				M. D. Canto, R. Melvold, and B. Kim A hybrid between a resistant and a susceptible strain of mouse alters the pattern of Theiler's murine encephalomyelitis virus-induced white matter disease and favors oligodendrocyte-mediated remyelination Multiple Sclerosis, June 1, 1995; 1(2): 95 - 103. [Abstract] [PDF]