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NEUROLOGY 1992;42:614
© 1992 American Academy of Neurology

Cerebral venous thrombosis in Behçet's disease

Clinical study and long-term follow-up of 25 cases

B. Wechsler, MD, M. Vidailhet, MD, J. C. Piette, MD, M. G. Bousser, MD, B. Dell Isola, MD, O. Blétry, MD and P. Godeau, MD

Service de Médecine Interne, Groupe Hospitalier Pitié-Salpetrière Paris, France (Drs. Wechsler, Vidailhet, Piette, Dell Isola, Blétry, and Godeau)
Service de Neurologie, Groupe Hospitalier Pitié-Salpetrière Paris, France (Dr. Vidailhet)
Service de Neurologie, Hôpital Saint Antoine, Paris, France (Dr. Bousser).

Among 250 patients with Behçet's disease, we describe 25 cases of angiographically proven cerebral venous thrombosis. Intracranial hypertension was the most frequent manifestation. Two initially untreated patients relapsed. Treatment of cerebral venous thrombosis consisted of combined heparin and steroids in 19 patients, steroids alone in three, and heparin alone in three others. Neurologic symptoms improved rapidly in all. Nineteen patients received long-term anticoagulation, and two received aspirin. Relapse of cerebral venous thrombosis or development of optic atrophy did not occur in treated patients. Partial or total recanalization of the occluded sinus was frequent. After more than 3 years of follow-up, the prognosis of dural sinus thrombosis is satisfactory.

Address correspondence and reprint requests to Dr. Jean Charles Piette, Service de Médecine Interne, Group Hospitalier Pitié-Salpetrière, 47–83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

Received February 22, 1991. Accepted for publication in final form August 20, 1991.




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