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NEUROLOGY 1992;42:640
© 1992 American Academy of Neurology

Fatal meningoencephalitis caused by reactivation of Trypanosoma cruzi infection in a patient with AIDS

S. Rosemberg, MD, C. J. Chaves, MD, M. L. Higuchi, MD, M.B.S. Lopes, MD, L. H.M. Castro, MD and L. R. Machado, MD

Departments of Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil (Drs. Rosemberg and Lopes)
Neuropathology Division, and Neurology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil (Drs. Chaves, Castro, and Machado)
Heart Institute, University of Sao Paulo School of Medicine, Sao Paulo, Brazil (Dr. Higuchi).

We report a case of fatal chagasic meningoencephalitis in an AIDS patient. Acute exacerbation of chronic Chagas' disease with involvement of the CNS is uncommon and occurs only in immunocompromised patients. This is the third such reported reactivation and it underscores the importance of considering Chagas' disease in HIV-positive patients from endemic regions.

Address correspondence and reprint requests to Dr. Sergio Rosemberg, Department of Pathology, Neuropathology Division, University of Sao Paulo School of Medicine, Av. Dr. Arnaldo, 455, CEP 01246, Sao Paulo, Brazil.

Received May 3, 1991. Accepted for publication in final form August 19, 1991.




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