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NEUROLOGY 1992;42:679
© 1992 American Academy of Neurology

Spontaneous regression of optic glioma in a patient with neurofibromatosis

Anita E. Brzowski, MD, Carlos Bazan, III, MD, John V. Mumma, MD and Stephen G. Ryan, MD

Section of Neurology, Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX (Drs. Brzowski and Ryan)
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (Dr. Bazan)
Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX (Dr. Mumma).

We describe a young girl with neurofibromatosis and enlargement of the optic chiasm and intracranial left optic nerve. Serial MRIs over 32 months demonstrated spontaneous, marked reduction in the size of these lesions. Spontaneous regression must be considered in evaluating therapies for optic glioma.

Address correspondence and reprint requests to Dr. Stephen G. Ryan, Section of Neurology, Department of Pediatrics, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284–7814.

Received April 30, 1991. Accepted for publication in final form August 8, 1991.




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