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NEUROLOGY 1992;42:749
© 1992 American Academy of Neurology

Sex but no hand difference in the isthmus of the corpus callosum

H. Steinmetz, MD, L. Jancke, PhD, A. Kleinschmidt, MD, G. Schlaug, MD, J. Volkmann and Y. Huang, BSc

Departments of Neurology, Heinrich-Heine University, Düsseldorf, Germany (Drs. Steinmetz, Kleinschmidt, and Schlaug, and J. Volkmann and Y. Huang)
Psychobiology and Psychocybernetics, Heinrich-Heine University, Düsseldorf, Germany (Dr. Jäncke).

We performed high-resolution magnetic resonance morphometry of the total midsagittal area and seven midsagittal subareas of the corpus callosum in healthy young adult dextrals and sinistrals (N = 52). There was no influence of handedness on these anatomic measurements. However, an effect of sex emerged, with women (N = 26) having a larger proportional isthmus segment of the callosum. This may reflect a sex-specific difference in the inter-hemispheric connectivity and functional organization of the temporoparietal association cortex.

Address correspondence and reprint requests to Dr. Helmuth Steinmetz, Department of Neurology, University Clinic, Heinrich-Heine University, Moorenstr. 5, W-4000 Düsseldorf 1, Federal Republic of Germany.

Supported by grants from the Deutsche Porschungsgemeinschaft (SFB 194/A7).

Received April 17, 1991. Accepted for publication in final form August 19, 1991.




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