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Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, IL (Drs. Goetz, Tanner, Stebbins, Leipzig, and Carr)
Clinical Center for Parkinson's Disease and Movement Disorders, San Jose, CA (Dr. Tanner).
We studied 58 adults with Gilles de la Tourette's syndrome diagnosed during childhood. Tics persisted in all patients but were moderate/severe in only 24%, compared with 60% at the time of worst function. Coprolalia persisted in 4%, compared with 22% at the time of worst function. For most patients, worst function occurred in adolescence (mode = 13 years). In spite of a high frequency of school and behavioral problems during development, 98% graduated high school and 90% were full-time students or fully employed. Features predictive of mild tic severity in adulthood were mild tics during the patient's worst pre-adulthood function and mild tics during early and late adolescence. Childhood tic severity had no predictive value, and likewise, coprolalia during development did not increase the risk for adult moderate/severe tics.
Address correspondence and reprint requests to Dr. C.G. Goetz, Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, 1725 W. Harrison St., Chicago, IL 60612.
Received June 12, 1991. Accepted for publication in final form September 10, 1991.
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